INT202646

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.46
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptf1a) nucleus (Ptf1a) intracellular (Ptf1a)
embryo development (Ptf1a) DNA binding (Ptf1a) cytoplasm (Ptf1a)
Anatomy Link Frequency
exocrine pancreas 1
spinal cord 1
exocrine cells 1
Ptf1a (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 18 97.64 Very High Very High Very High
Spinal cord 52 96.92 Very High Very High Very High
gABA 28 94.20 High High
Dorsal horn 6 85.96 High High
Dorsal horn neuron 2 72.60 Quite High
bDMF 49 5.00 Very Low Very Low Very Low
Neurotransmitter 31 5.00 Very Low Very Low Very Low
fibrosis 14 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 21 87.28 High High
Death 22 68.88 Quite High
Apoptosis 61 61.44 Quite High
Targeted Disruption 150 51.20 Quite High
Ganglion Cysts 54 5.00 Very Low Very Low Very Low
Sprains And Strains 49 5.00 Very Low Very Low Very Low
Pancreatic Cancer 42 5.00 Very Low Very Low Very Low
Pancreatitis 28 5.00 Very Low Very Low Very Low
Fibrosis 14 5.00 Very Low Very Low Very Low
Metaplasia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The persistence of PTF1 protein expression in vitro may reflect onset of its expression prior to inhibitor addition.
Gene_expression (expression) of PTF1
1) Confidence 0.48 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.14 Pain Relevance 0
In addition, although p48/PTF1 is necessary for exocrine pancreas development, it is unlikely that all exocrine genes are direct targets of p48/PTF1.
Gene_expression (targets) of PTF1 in exocrine pancreas
2) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.07 Pain Relevance 0
Failure to effectively initiate an exocrine differentiation program might be due to reduced levels of p48/PTF1 in the ?
Gene_expression (levels) of PTF1
3) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
Failure to effectively initiate an exocrine differentiation program might be due to reduced levels of p48/PTF1 in the ?
Gene_expression (/) of PTF1
4) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
Next, we evaluated the expression of PTF1A-p48, whose expression become restricted to exocrine cells at approximately E12.5.
Gene_expression (expression) of PTF1A-p48 in exocrine cells
5) Confidence 0.37 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.11 Pain Relevance 0
Alternatively, loss of PTF1 expression that we observed in vivo may be regulated by a Wnt independent function of ?
Gene_expression (expression) of PTF1
6) Confidence 0.37 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.14 Pain Relevance 0
A transcription factor of unknown function, the leucine zipper-like transcription factor1 (Lzltf1), was among the most reduced genes at E14.5, with its expression being decreased by an average of 5.9 fold.
Gene_expression (expression) of transcription factor1
7) Confidence 0.33 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
These include Olig3, Neurog2(Ngn2), Ascl1(Mash1), Gsh1, Gsh2, Math1, Pax3, Pax7, and Ptf1a.
Gene_expression (include) of Ptf1a
8) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
According to these authors Ptf1a appears to act as a master regulator of developing inhibitory neurons of the dorsal spinal cord, and can act in conjunction with Lbx1 to activate Pax2 as a downstream target.
Gene_expression (appears) of Ptf1a in spinal cord associated with spinal cord
9) Confidence 0.23 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.29
One such bHLH transcription factor is neurogenin 2 (Ngn2).
Gene_expression (is) of bHLH transcription factor
10) Confidence 0.11 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0

General Comments

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