INT20265

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 1997
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 1.01
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) response to stress (Ctsb) lysosome (Ctsb)
Anatomy Link Frequency
brain 1
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 19 99.98 Very High Very High Very High
Morphine 20 99.92 Very High Very High Very High
Opioid 3 99.80 Very High Very High Very High
substance P 1 75.36 Quite High
medulla 1 69.04 Quite High
bradykinin 4 53.60 Quite High
B1 receptor 1 48.40 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 12 99.62 Very High Very High Very High
Death 2 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Splenocytes from morphine treated rats also showed increased mRNA expression of cathepsin-B, a gene associated with active cell death.
Gene_expression (expression) of cathepsin-B associated with death and morphine
1) Confidence 0.47 Published 1997 Journal Inflammation Section Abstract Doc Link 9429908 Disease Relevance 0.50 Pain Relevance 0.83
Morphine induces splenocyte apoptosis and enhanced mRNA expression of cathepsin-B.
Gene_expression (expression) of cathepsin-B associated with apoptosis and morphine
2) Confidence 0.47 Published 1997 Journal Inflammation Section Title Doc Link 9429908 Disease Relevance 0.52 Pain Relevance 0.85
Preferential action of rat brain cathepsin B as a peptidyl dipeptidase converting pro-opioid oligopeptides.
Gene_expression (converting) of cathepsin B in brain associated with enkephalin and opioid
3) Confidence 0.41 Published 1986 Journal Arch. Biochem. Biophys. Section Title Doc Link 3530135 Disease Relevance 0 Pain Relevance 0.65
The EK-producing activity of the cathepsin B was demonstrated using the partially purified EK precursor protein from the pulp tissue as a substrate.
Gene_expression (producing) of cathepsin B associated with enkephalin
4) Confidence 0.22 Published 1990 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 2130176 Disease Relevance 0 Pain Relevance 1.19

General Comments

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