INT20266

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 60
Total Number 77
Disease Relevance 63.64
Pain Relevance 56.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
microglia 8
spinal cord 4
astrocytes 4
nerve 2
heart 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 3643 100.00 Very High Very High Very High
bradykinin 1052 100.00 Very High Very High Very High
c fibre 90 100.00 Very High Very High Very High
Spinal cord 818 99.98 Very High Very High Very High
intrathecal 399 99.98 Very High Very High Very High
addiction 3 99.92 Very High Very High Very High
antagonist 690 99.84 Very High Very High Very High
cytokine 210 99.84 Very High Very High Very High
b2 receptor 23 99.80 Very High Very High Very High
Hyperalgesia 315 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1706 100.00 Very High Very High Very High
Nociception 238 99.98 Very High Very High Very High
Stress 624 99.96 Very High Very High Very High
Pressure And Volume Under Development 333 99.92 Very High Very High Very High
Diabetes Complications 68 99.92 Very High Very High Very High
Hyperalgesia 563 99.74 Very High Very High Very High
Hypertension 102 99.74 Very High Very High Very High
INFLAMMATION 525 99.72 Very High Very High Very High
Interstitial Cystitis 2 99.70 Very High Very High Very High
Hemorrhagic Shock 1 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant increase of B1 receptor mRNA in the zymosan--but not the saline-injected paw at 6 h.
Positive_regulation (increase) of B1 receptor mRNA in paw associated with b1 receptor
1) Confidence 0.69 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10647872 Disease Relevance 0.77 Pain Relevance 1.52
Since the B1 receptor may be induced under inflammatory situations, we examined the amount of corresponding mRNA using quantitative RT-PCR.
Spec (may) Positive_regulation (induced) of B1 receptor associated with inflammation and b1 receptor
2) Confidence 0.69 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10647872 Disease Relevance 0.78 Pain Relevance 1.42
Kinin B1 receptor (B1R) is induced by the oxidative stress in models of diabetes mellitus.
Positive_regulation (induced) of B1R associated with stress, diabetes mellitus and b1 receptor
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 0.73 Pain Relevance 0.39
B) pathway [40], [41] which is directly involved in the upregulation of B1R [4].
Positive_regulation (upregulation) of B1R associated with b1 receptor
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.11 Pain Relevance 0.38
This is consistent with the increased B1R mRNA and protein expression following a 12 h exposure of mesenteric vascular endothelial cells with 25 mM glucose [39].
Positive_regulation (increased) of B1R mRNA in endothelial cells associated with b1 receptor
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.24 Pain Relevance 0.42
This study aims at determining whether B1R activation could perpetuate the oxidative stress which leads to diabetic complications.


Positive_regulation (activation) of B1R associated with stress, diabetes complications and b1 receptor
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 0.82 Pain Relevance 0.41
Kinin B1 receptor (B1R) is induced by the oxidative stress in models of diabetes mellitus.
Positive_regulation (induced) of Kinin B1 receptor associated with stress, diabetes mellitus and b1 receptor
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 0.73 Pain Relevance 0.39
It is hypothesised that activation of B1R increases oxidative stress (aortic O2•?)
Positive_regulation (activation) of B1R associated with stress and b1 receptor
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.20 Pain Relevance 0.74
and that its prolonged inhibition reverses oxidative stress and the subsequent upregulation of B1R which is responsible for arterial hypertension and pain polyneuropathy.
Positive_regulation (upregulation) of B1R associated with neuropathy, stress, pain, pressure and volume under development and b1 receptor
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.26 Pain Relevance 0.73
The corollary of these findings is that the oxidative stress is likely the primary mechanism involved in the induction of B1R in the model of insulin resistance induced by high glucose intake.
Positive_regulation (induction) of B1R associated with stress, b1 receptor and insulin resistance
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.11 Pain Relevance 0.38
Recent studies highlighted a primary role for the inducible kinin B1 receptor (B1R) in mediation of nociception and diabetes-induced neuropathic pain [6,7].
Positive_regulation (inducible) of kinin B1 receptor associated with nociception, diabetes mellitus, b1 receptor and neuropathic pain
11) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.97 Pain Relevance 1.18
In diabetic rats, the intrathecal stimulation of B1R with its native agonist (des-Arg9-BK, 9.6 nmol) induced a significant and transient enhancement of tactile allodynia at 10 min post-injection.
Positive_regulation (stimulation) of B1R associated with brush evoked pain, diabetes mellitus, b1 receptor, agonist, bradykinin and intrathecal
12) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.31 Pain Relevance 1.45
Recent studies highlighted a primary role for the inducible kinin B1 receptor (B1R) in mediation of nociception and diabetes-induced neuropathic pain [6,7].
Positive_regulation (inducible) of B1R associated with nociception, diabetes mellitus, b1 receptor and neuropathic pain
13) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.97 Pain Relevance 1.18
Since pro-inflammatory cytokines are involved in the induction of B1R and that TRPV1 is associated with pain neuropathy, this series of experiments was carried out to measure their expression in STZ-diabetic rats.
Positive_regulation (induction) of B1R associated with pain, inflammation, diabetes mellitus, b1 receptor, neuropathic pain and cytokine
14) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.60 Pain Relevance 0.78
Importantly, this study presented the first evidence that spinal cord activation of B1R with its native agonist enhanced tactile allodynia in STZ-diabetic rats.
Positive_regulation (activation) of B1R in spinal cord associated with brush evoked pain, diabetes mellitus, b1 receptor, agonist and spinal cord
15) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.60 Pain Relevance 1.42
We conclude that B1 and B2 receptor mRNA are differentially expressed in the hypothalamus of SHR and may play different roles in the pathogenesis of hypertension: upregulation of B2 receptor mRNA from early age may participate in the pathogenesis of hypertension, whereas an upregulation of B1 receptor mRNA in the established phase of hypertension may reflect an epiphenomenon in essential hypertension.
Positive_regulation (upregulation) of B1 receptor mRNA in hypothalamus associated with b1 receptor, hypertension and b2 receptor
16) Confidence 0.60 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 1.02 Pain Relevance 0.35
BACKGROUND: The pro-nociceptive kinin B1 receptor (B1R) is upregulated on sensory C-fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat.
Positive_regulation (upregulated) of B1R in microglia associated with nociception, c fibre, diabetes mellitus, b1 receptor and spinal cord
17) Confidence 0.50 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link 20587056 Disease Relevance 0.42 Pain Relevance 0.53
BACKGROUND: The pro-nociceptive kinin B1 receptor (B1R) is upregulated on sensory C-fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat.
Positive_regulation (upregulated) of kinin B1 receptor in microglia associated with nociception, c fibre, diabetes mellitus, b1 receptor and spinal cord
18) Confidence 0.50 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link 20587056 Disease Relevance 0.42 Pain Relevance 0.53
In DRG, B1R and B2R binding sites were significantly increased at 2 days (ipsilateral) and 14 days on both sides.
Positive_regulation (increased) of B1R in DRG
19) Confidence 0.49 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.81 Pain Relevance 1.03
The B1R is activated by the active metabolites des-Arg9-BK and Lys-des-Arg9-BK and has a low level of expression in healthy tissues [10].
Positive_regulation (activated) of B1R associated with b1 receptor and bradykinin
20) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.05 Pain Relevance 1.45

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