INT202728

Context Info Confidence 0.54 First Reported 2007 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 1.19 Pain Relevance 0.28

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8) cytoplasm (Map3k8)

Anatomy Link Frequency macrophages 1 Map3k8 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory stimuli 10 96.28 Acupuncture 42 89.56 Inflammatory mediators 4 68.84 cytokine 78 64.00 Inflammation 52 41.76 Pain 52 5.00 long-term potentiation 14 5.00 Pain threshold 14 5.00 Calcitonin gene-related peptide 11 5.00 transcutaneous nerve stimulation 10 5.00

Disease Link Frequency Relevance Heat Obesity 212 97.84 INFLAMMATION 66 95.96 Cancer 10 50.00 Necrosis 6 50.00 Pain 66 5.00 Insulin Resistance 20 5.00 Diabetes Mellitus 16 5.00 Hypertension 2 5.00 Impaired Glucose Tolerance 2 5.00 Dislocations 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B1/p105, triggering its proteolysis and the release and activation of Tpl2.

Localization (release) of Tpl2

1) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.59 Pain Relevance 0.11

Indeed, in nonstimulated macrophages, Tpl2 is stabilized and is inactive due to its binding to NF-?

Localization (stabilized) of Tpl2 in macrophages

2) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.08

Change of EST

Localization (Change) of EST

3) Confidence 0.39 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.04

EST increase was reported by 5 (23%) of the 22 women, unchanged by 11 (50%) and a decreased EST by the remaining 6 (27%) women.

Neg (unchanged) Localization (decreased) of EST

4) Confidence 0.39 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.04

This is an EST and is not found in LocusLink [20].

Neg (not) Localization (found) of EST

5) Confidence 0.04 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1784106 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.