INT20274

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 5.55
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
neutrophils 2
neuronal 1
neuron 1
Aap (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 457 100.00 Very High Very High Very High
cva 15 69.12 Quite High
Analgesic 3 54.12 Quite High
Restless leg syndrome 1 28.08 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 49 99.96 Very High Very High Very High
Hepatotoxicity 17 99.64 Very High Very High Very High
Death 99 99.28 Very High Very High Very High
Injury 55 98.50 Very High Very High Very High
Adhesions 4 98.40 Very High Very High Very High
Apoptosis 44 98.12 Very High Very High Very High
Necrosis 26 92.92 High High
Overdose 24 87.92 High High
Pressure And Volume Under Development 12 83.28 Quite High
Stress 15 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pH of the dissolution fluid or the storage at room temperature for 120 days had little affect on AAP release from the AYC-coated tablets.
Neg (little) Regulation (affect) of AAP associated with paracetamol
1) Confidence 0.45 Published 2000 Journal Int J Pharm Section Abstract Doc Link 11011986 Disease Relevance 0 Pain Relevance 0.42
In addition, antibodies against CD18, the common subunit of beta2 integrins, which functionally inactivate hepatic neutrophils [30,31], had no effect on AAP-induced hepatotoxicity [6].
Neg (no) Regulation (effect) of AAP in neutrophils associated with paracetamol and hepatotoxicity
2) Confidence 0.36 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410261 Disease Relevance 1.23 Pain Relevance 0.52
We therefore determined in mice the effects of hepatotoxic doses of AAP on the messenger RNA for intercellular adhesion molecule-1 (ICAM-1), which is a critical determinant of neutrophil adhesion, activation and ultimately of neutrophil-mediated tissue injury.
Spec (determined) Regulation (effects) of AAP in neutrophil associated with paracetamol, injury and adhesions
3) Confidence 0.35 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 0.72 Pain Relevance 0.49
These results show that it is feasible to control the lag time and the release rate of AAP from AYC-coated tablets by varying the curing time and temperature.
Regulation (control) of AAP associated with paracetamol
4) Confidence 0.29 Published 2000 Journal Int J Pharm Section Abstract Doc Link 11084247 Disease Relevance 0.09 Pain Relevance 0.16
Treatment with the caspase inhibitor ZVAD-CHF2 had no effect on AAP toxicity but completely prevented Jo-mediated apoptosis.
Neg (no) Regulation (effect) of AAP associated with toxicity, paracetamol and apoptosis
5) Confidence 0.24 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10222310 Disease Relevance 0.81 Pain Relevance 0.87
The purpose of this study was several-fold: (i) to examine the hepatoprotective ability of short-term (3-day) and long-term (7-day) exposures of a grape seed proanthocyanidin extract (GSPE) on AAP-induced liver injury and animal lethality; (ii) to monitor effects of GSPE on one of the prime targets of AAP, i.e., hepatocellular genomic DNA and associated apoptotic and necrotic death; and (iii) to unravel changes in the pattern of expression of an antiapoptotic gene, bcl-Xl in the liver.
Regulation (targets) of AAP in liver associated with paracetamol, injury, apoptosis and death
6) Confidence 0.22 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.79 Pain Relevance 0.65
The effects of potassium ethylxanthogenate (PEX), acetaminophen (AAP) and their combination on the activity of serum transaminases, liver glutathione level and the activity of some drug metabolizing enzyme systems in male albino mice are studied.
Regulation (effects) of AAP in liver associated with paracetamol
7) Confidence 0.17 Published 1990 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2130626 Disease Relevance 0.07 Pain Relevance 0.57
Mitochondrial role in AAP-induced neuronal death
Regulation (role) of AAP in neuronal associated with paracetamol and death
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.86 Pain Relevance 0.94
Since AAP is found unaltered in the brain and AAP increases CYP2E1 expression and activity, AAP could induce cortical neuron apoptosis due to increased local NAPQI production through CYP2E1 enzymatic activity.
Regulation (unaltered) of AAP in neuron associated with paracetamol and apoptosis
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.40 Pain Relevance 1.03
We used different concentrations of AAP - 1, 2.5, 5, 10 and 20 mM, to test influence of AAP on cellular viability, functional capacity and oxidative status at given time intervals.
Regulation (influence) of AAP associated with paracetamol
10) Confidence 0.05 Published 2009 Journal Physiol Res Section Abstract Doc Link 18380536 Disease Relevance 0.10 Pain Relevance 0.76
We investigated the regulation of antioxidant system under acetaminophen (AAP) toxicity.
Spec (investigated) Regulation (regulation) of AAP associated with toxicity and paracetamol
11) Confidence 0.01 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19039654 Disease Relevance 0.25 Pain Relevance 0.36
There were no changes in mRNA expression levels of SOD, CAT, and GSH-Px after AAP treatment compared to control group.
Neg (no) Regulation (changes) of AAP associated with paracetamol
12) Confidence 0.01 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19039654 Disease Relevance 0.22 Pain Relevance 0.49

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