INT20275

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Context Info
Confidence 0.20
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.62
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Abo) transferase activity, transferring glycosyl groups (Abo) Golgi apparatus (Abo)
carbohydrate metabolic process (Abo)
Anatomy Link Frequency
saliva 1
Abo (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 10 99.60 Very High Very High Very High
intrathecal 6 99.28 Very High Very High Very High
Paracetamol 44 99.22 Very High Very High Very High
Thermal hyperalgesia 3 98.04 Very High Very High Very High
withdrawal 1 94.24 High High
Spinal cord 3 89.92 High High
Inflammation 23 83.80 Quite High
Hyperalgesia 1 82.20 Quite High
Kinase C 20 79.28 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Syndrome 8 99.06 Very High Very High Very High
Disease 32 98.96 Very High Very High Very High
Hyperuricemia 38 98.94 Very High Very High Very High
Hyperalgesia 4 98.04 Very High Very High Very High
Myeloid Leukemia 32 97.68 Very High Very High Very High
Neuroblastoma 72 96.24 Very High Very High Very High
Cerebral Palsy 1 95.52 Very High Very High Very High
Crystal Associated Disease 71 94.88 High High
Spasticity 1 94.16 High High
Toxicity 21 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eighteen hours after the administration of a hepatotoxic dose of AAP, there is a statistically significant decrease of the activity of aniline hydroxylase, ethylmorphine demethylase, uridine diphosphoglucuronyl transferase, glutathione-S-transferase, NADPH-cytochrome-c-reductase, the P-450 content and a 5-fold increase of TBA-reactive products.
Negative_regulation (decrease) of transferase associated with paracetamol
1) Confidence 0.20 Published 1990 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2130626 Disease Relevance 0.07 Pain Relevance 0.77
The Lesch-Nyhan syndrome results from a complete or virtually complete deficiency of the purine salvage enzyme, hypoxanthine guanine phosphoribosyl transferase (HPRT).
Negative_regulation (deficiency) of transferase associated with syndrome
2) Confidence 0.19 Published 1996 Journal Nippon Rinsho Section Abstract Doc Link 8976112 Disease Relevance 0.81 Pain Relevance 0.08
Intrathecal pretreatment with a geranylgeranyl transferase I inhibitor GGTI-2133 (0.001-1.0 nmol) or a ROCK inhibitor Y27632 (0.001-1.0 nmol) completely blocked the mevalonate-induced thermal hyperalgesia.
Negative_regulation (inhibitor) of transferase associated with thermal hyperalgesia and intrathecal
3) Confidence 0.18 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.69 Pain Relevance 0.77
In vitro biochemical studies indicated that ether anesthesia produced a delayed reduction in the activities of glucuronyl transferase and glutathione (GSH) S-transferase, and in the hepatic content of GSH.
Negative_regulation (reduction) of transferase associated with anesthesia
4) Confidence 0.18 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3790145 Disease Relevance 0.16 Pain Relevance 0.83
In vitro biochemical studies indicated that ether anesthesia produced a delayed reduction in the activities of glucuronyl transferase and glutathione (GSH) S-transferase, and in the hepatic content of GSH.
Negative_regulation (reduction) of transferase associated with anesthesia
5) Confidence 0.18 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3790145 Disease Relevance 0.16 Pain Relevance 0.76
Eighteen hours after the administration of a hepatotoxic dose of AAP, there is a statistically significant decrease of the activity of aniline hydroxylase, ethylmorphine demethylase, uridine diphosphoglucuronyl transferase, glutathione-S-transferase, NADPH-cytochrome-c-reductase, the P-450 content and a 5-fold increase of TBA-reactive products.
Negative_regulation (decrease) of transferase associated with paracetamol
6) Confidence 0.15 Published 1990 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2130626 Disease Relevance 0.07 Pain Relevance 0.78
None of the nonsecretors who were also Lewis negative (n = 3), hence lacking the Lea antigen and ABO in saliva, were symptomatically infected.
Negative_regulation (lacking) of ABO in saliva
7) Confidence 0.07 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874438 Disease Relevance 0.49 Pain Relevance 0
Finally, long-term treatment of CML may require a combination of both conventional and targeted compounds such as tyrosine kinase inhibitors, farnesyl transferase inhibitors, and possibly compounds with other mechanisms of action like vaccines, to stimulate patient immunity and possibly control and eliminate residual disease.


Spec (possibly) Negative_regulation (inhibitors) of transferase associated with myeloid leukemia and disease
8) Confidence 0.03 Published 2010 Journal Core evidence Section Body Doc Link PMC2899790 Disease Relevance 0.41 Pain Relevance 0
The chemotherapeutic drug CHS 828 is a pyridylguanidine that potently inhibits nicotinamide phosphoribosyl transferase (NAMPT) in a time dependent manner [12,13].
Negative_regulation (inhibits) of transferase
9) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2667491 Disease Relevance 0.49 Pain Relevance 0
A farnesyl transferase inhibitor also increased sAPP?
Negative_regulation (inhibitor) of transferase
10) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC543463 Disease Relevance 0.28 Pain Relevance 0.04
Treatment of cells with a farnesyl transferase inhibitor or expression of a dominant negative (DN) ROCK1 molecule led to enhanced sAPP?
Negative_regulation (inhibitor) of transferase
11) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.07 Pain Relevance 0
Each substrate protein was reacted under standard conditions with vehicle, specific transferase inhibitor or ZOL.
Negative_regulation (inhibitor) of transferase
12) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0 Pain Relevance 0
The well-known monogenic causes of hyperuricemia, such as HGPRT (hypoxanthine-guanine phosphoribosyl transferase) deficiency and PRPP (phosphoribosylpyrophosphate) synthetase overactivity, account for but a small fraction of cases of hyperuricemia and gout.
Negative_regulation (deficiency) of transferase associated with hyperuricemia and crystal associated disease
13) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.91 Pain Relevance 0

General Comments

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