INT20276

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Context Info
Confidence 0.07
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Abo) transferase activity, transferring glycosyl groups (Abo) Golgi apparatus (Abo)
carbohydrate metabolic process (Abo)
Anatomy Link Frequency
liver 1
tail 1
Abo (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 21 99.98 Very High Very High Very High
agonist 31 93.36 High High
Inflammation 15 87.12 High High
metalloproteinase 5 80.12 Quite High
Inflammatory response 2 59.60 Quite High
cva 2 25.00 Low Low
Bile 9 22.68 Low Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 97.28 Very High Very High Very High
Injury 5 94.48 High High
INFLAMMATION 18 87.12 High High
Hepatotoxicity 3 75.00 Quite High
Pressure And Volume Under Development 1 56.96 Quite High
Poisoning 1 51.76 Quite High
Obesity 14 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eighteen hours after the administration of a hepatotoxic dose of AAP, there is a statistically significant decrease of the activity of aniline hydroxylase, ethylmorphine demethylase, uridine diphosphoglucuronyl transferase, glutathione-S-transferase, NADPH-cytochrome-c-reductase, the P-450 content and a 5-fold increase of TBA-reactive products.
Positive_regulation (increase) of transferase associated with paracetamol
1) Confidence 0.07 Published 1990 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2130626 Disease Relevance 0.07 Pain Relevance 0.76
APAP increased alanine transferase (ALT) levels (41.1-fold) and resulted in centrilobular hemorrhagic necrosis at 6 h.
Positive_regulation (increased) of alanine transferase associated with necrosis and paracetamol
2) Confidence 0.07 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15456921 Disease Relevance 0.46 Pain Relevance 0.96
While others, such as hypoxanthine-quanidine phosphoribosyl transferase, with a CPE and a short poly A+ tail are polyadenylated during maturation.
Positive_regulation (polyadenylated) of transferase in tail
3) Confidence 0.03 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0 Pain Relevance 0
The observed increase in plasma alanine amino transferase activity in patients treated with fibrates may thus be related to direct regulation of Gpt transcription, rather than drug-induced liver injury.

10.

Positive_regulation (increase) of plasma alanine amino transferase in liver associated with injury
4) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.50 Pain Relevance 0.26

General Comments

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