INT202786

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.16
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pin1) protein folding (Pin1) nucleus (Pin1)
cell cycle (Pin1) cytoplasm (Pin1)
Anatomy Link Frequency
eosinophils 1
T lymphocytes 1
Pin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 150 98.08 Very High Very High Very High
Inflammation 30 68.48 Quite High
fibrosis 10 60.52 Quite High
cva 5 56.68 Quite High
Multiple sclerosis 5 53.92 Quite High
isoflurane 25 29.60 Quite Low
chemokine 10 12.80 Low Low
corticosteroid 5 9.24 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 80 99.96 Very High Very High Very High
Recurrence 5 98.52 Very High Very High Very High
Cancer 10 98.08 Very High Very High Very High
Toxicity 20 92.32 High High
Graft Vs Host Disease 30 88.20 High High
Adhesions 5 69.64 Quite High
INFLAMMATION 30 68.48 Quite High
Communicable Diseases 5 60.56 Quite High
Fibrosis 10 60.52 Quite High
Infection 5 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we implicated Pin1 in the post-transcriptional control of GM-CSF mRNA by activated eosinophils and T lymphocytes [12], [13].
Regulation (control) of Pin1 in T lymphocytes
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.41 Pain Relevance 0.18
Here we show in vitro, using either Pin1 KO or juglone-treated splenocytes from WT rats that Pin1 activity is required to stabilize, accumulate and translate mRNAs coding for several type-1 cytokines including IFN-?
Regulation (using) of Pin1 associated with targeted disruption and cytokine
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.16 Pain Relevance 0.12
The initially identified Pin1 targets were cell cycle regulators particularly mitotic kinases [9].
Regulation (targets) of Pin1
3) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.51 Pain Relevance 0.20
Based on prior work, Pin1 likely functions through direct interactions with and regulation of key AUUUA specific, mRNA binding proteins such as AUF1, HnRNP C and HuR [12], [13].
Regulation (regulation) of Pin1
4) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.67 Pain Relevance 0.14
Recently, we implicated Pin1 in the post-transcriptional control of GM-CSF mRNA by activated eosinophils and T lymphocytes [12], [13].
Regulation (control) of Pin1 in eosinophils
5) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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