INT202790

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.02
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pin1) protein folding (Pin1) nucleus (Pin1)
cell cycle (Pin1) cytoplasm (Pin1)
Pin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 180 98.08 Very High Very High Very High
Multiple sclerosis 6 97.92 Very High Very High Very High
isoflurane 30 82.32 Quite High
cva 6 77.92 Quite High
Inflammation 36 76.88 Quite High
fibrosis 12 60.52 Quite High
corticosteroid 6 30.48 Quite Low
chemokine 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 6 98.32 Very High Very High Very High
Demyelinating Disease 6 97.92 Very High Very High Very High
Diabetes Mellitus 6 97.12 Very High Very High Very High
Autoimmune Disease 6 96.72 Very High Very High Very High
Communicable Diseases 6 94.64 High High
Toxicity 24 92.32 High High
Graft Vs Host Disease 36 91.76 High High
Adhesions 6 78.04 Quite High
Hemorrhage 6 77.92 Quite High
INFLAMMATION 36 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A third PPIase, Pin1, binds to and isomerizes only phosphorylated Ser/Thr-Pro motifs.
Pin1 Binding (binds) of
1) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.60 Pain Relevance 0.27
Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.
Pin1 Binding (interacts) of
2) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07
suggest a role for Pin1 in these processes as well.


Pin1 Binding (role) of
3) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.78 Pain Relevance 0.17
Interference with Pin1 through pharmacologic or genetic means reduced IFN-?
Pin1 Binding (Interference) of
4) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.71 Pain Relevance 0.15
Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.
Pin1 Binding (interacts) of
5) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07
Based on prior work, Pin1 likely functions through direct interactions with and regulation of key AUUUA specific, mRNA binding proteins such as AUF1, HnRNP C and HuR [12], [13].
Pin1 Binding (interactions) of
6) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.66 Pain Relevance 0.14

General Comments

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