INT202792

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 3.77
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pin1) protein folding (Pin1) nucleus (Pin1)
cell cycle (Pin1) cytoplasm (Pin1)
Anatomy Link Frequency
lymph nodes 1
immune cell 1
lung 1
Pin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 480 99.80 Very High Very High Very High
fibrosis 32 97.04 Very High Very High Very High
cva 16 96.80 Very High Very High Very High
chemokine 32 94.64 High High
Inflammation 96 94.48 High High
corticosteroid 16 80.56 Quite High
isoflurane 80 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
Thoracotomy 16 5.00 Very Low Very Low Very Low
Multiple sclerosis 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Graft Vs Host Disease 96 98.64 Very High Very High Very High
Fibrosis 32 97.04 Very High Very High Very High
Hemorrhage 16 96.80 Very High Very High Very High
Toxicity 64 95.56 Very High Very High Very High
INFLAMMATION 96 94.48 High High
Congenital Anomalies 16 94.00 High High
Targeted Disruption 256 90.20 High High
Death 16 85.76 High High
Cytomegalovirus Infection 16 77.64 Quite High
Recurrence 16 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a variable sensitivity of cytokine mRNAs to Pin1 inhibition.
Negative_regulation (inhibition) of Pin1 associated with cytokine
1) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.23 Pain Relevance 0.13
and CXCL-10 in the process of acute rejection and suggest that cytokine suppression after Pin1 inhibition is likely responsible for graft sparing.
Negative_regulation (inhibition) of Pin1 associated with cytokine
2) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.31 Pain Relevance 0.22
Based on our data, we favor three explanations for graft survival after Pin1 inhibition.
Negative_regulation (inhibition) of Pin1
3) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.50 Pain Relevance 0.22
Irrespective of molecular mechanism, suppression of Pin1 clearly prevented acute and chronic graft rejection.
Negative_regulation (suppression) of Pin1 associated with graft vs host disease
4) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.45 Pain Relevance 0.20
Blockade of Pin1 by pharmacologic or genetic means greatly attenuated IFN-?
Negative_regulation (Blockade) of Pin1
5) Confidence 0.41 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0.13
These data suggest Pin1 inhibitors should be explored for use as immunosuppressants and employed with available calcineurin inhibitors to reduce toxicity and enhance effectiveness.



Negative_regulation (inhibitors) of Pin1 associated with toxicity
6) Confidence 0.41 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1790862 Disease Relevance 0.10 Pain Relevance 0.10
Combined transcriptional and post-transcriptional blockade with cyclosporine A and the Pin1 inhibitor, juglone, was synergistic.


Negative_regulation (inhibitor) of Pin1
7) Confidence 0.41 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0.11
and CXCL-10 within the graft and demonstration that Pin1 blockade was unable to prevent immune cell infiltration and rejection.
Negative_regulation (blockade) of Pin1 in immune cell
8) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.39 Pain Relevance 0.15
Once inactivated by juglone, Pin1 is rapidly degraded by the proteasome [12].
Negative_regulation (inactivated) of Pin1
9) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.11
Therefore, Pin1 inhibition prevented IFN-?
Negative_regulation (inhibition) of Pin1
10) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.11
These data demonstrate that Pin1 blockade can dramatically attenuate acute transplant rejection.
Negative_regulation (blockade) of Pin1 associated with graft vs host disease
11) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.24 Pain Relevance 0.14
These data show that combined inhibition of Pin1 and calcineurin are additive or synergistic and suggest that CsA dosage could be signifcantly reduced if Pin1 inhibition is added to the therapeutic regiment.


Negative_regulation (inhibition) of Pin1
12) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.09 Pain Relevance 0.10
Similarly, suboptimal inhibition of Pin1 leads to severe rejection pathology with substantial cellular infiltration and hemorrhage (Figure 6).
Negative_regulation (inhibition) of Pin1 associated with cva
13) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.14
At day 7, Pin1 PPIase activity and amount were attenuated in BAL cells and draining lymph nodes in juglone treated rats (figure 5A–C).
Negative_regulation (attenuated) of Pin1 PPIase in lymph nodes
14) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.11
While it is unlikely juglone would be employed clinically, these data are encouraging for the development of additional Pin1 inhibitors.
Negative_regulation (inhibitors) of Pin1
15) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.44 Pain Relevance 0.19
We show that mismatched lung transplants are not rejected if Pin1 is inhibited.
Negative_regulation (inhibited) of Pin1 in lung
16) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.41 Pain Relevance 0.19

General Comments

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