INT20280

Context Info Confidence 0.69 First Reported 1988 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 32 Total Number 32 Disease Relevance 18.37 Pain Relevance 5.69

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)

Anatomy Link Frequency liver 4 pituitary 2 erythrocytes 1 interneurons 1 sacroiliac joint 1 Esr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat COX2 12 100.00 backache 4 100.00 Inflammation 50 99.98 agonist 53 99.20 Potency 10 99.16 antagonist 61 98.92 Dopamine 85 98.70 Bioavailability 2 97.00 spinal dorsal horn 6 96.88 GABAergic 4 96.76

Disease Link Frequency Relevance Heat Low Back Pain 5 100.00 INFLAMMATION 45 99.98 Congenital Anomalies 62 99.88 Arthritis 60 99.84 Hepatomegaly 8 99.52 Otitis Media 8 99.52 Osteomyelitis 148 99.28 Traumatic Shock 72 99.28 Fever 15 98.72 Crush Syndrome 72 98.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The most common laboratory abnormalities were elevation of ESR, which was significantly more common in females than in males (P = 0.047).

Positive_regulation (elevation) of ESR associated with congenital anomalies

1) Confidence 0.69 Published 1990 Journal J Med Assoc Thai Section Abstract Doc Link 2212916 Disease Relevance 0.70 Pain Relevance 0.09

In searching for the molecular mechanisms leading from the initial activation of the estrogen receptor to the final formation of new dendritic spines, we found that estradiol acts on GABAergic interneurons expressing the estrogen receptor by decreasing their inhibitory tone.

Positive_regulation (activation) of estrogen receptor in interneurons associated with gabaergic

2) Confidence 0.49 Published 2001 Journal Horm Behav Section Abstract Doc Link 11534976 Disease Relevance 0 Pain Relevance 0.21

Contrary to the study of Sengupta et al. [4] the frequency of elevated ESR among our patients was not significantly different between these two histological subtypes.

Positive_regulation (elevated) of ESR

3) Confidence 0.41 Published 2008 Journal BMC Urol Section Body Doc Link PMC2635370 Disease Relevance 1.00 Pain Relevance 0

In agreement with other studies, [4,22] we found that elevated ESR at presentation was associated with more aggressive disease and poorer outcome for both clear cell and papillary RCC (data not shown).

Positive_regulation (elevated) of ESR associated with renal cancer and disease

4) Confidence 0.41 Published 2008 Journal BMC Urol Section Body Doc Link PMC2635370 Disease Relevance 0.84 Pain Relevance 0

On the other hand, an increased ESR in patients with traumatic shock and crush syndrome is due to an increased number of rouleaux, however, as it has been shown earlier, the quantity of rouleaux is largely dependent on the quantity of erythrocytes [47].

Positive_regulation (increased) of ESR in erythrocytes associated with traumatic shock and crush syndrome

5) Confidence 0.41 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1090599 Disease Relevance 0.82 Pain Relevance 0.04

Those with elevated ESR have been shown to have a much higher risk for recurrence [7].

Positive_regulation (elevated) of ESR associated with recurrence

6) Confidence 0.41 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1090599 Disease Relevance 1.15 Pain Relevance 0.26

According to our current research, increased ESR in patients with traumatic shock and crush syndrome is due to an increased number of rouleaux.

Positive_regulation (increased) of ESR associated with traumatic shock and crush syndrome

7) Confidence 0.41 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1090599 Disease Relevance 1.14 Pain Relevance 0.04

The ESR has been shown to be elevated in 55% of patients with otitis media [7].

Positive_regulation (elevated) of ESR associated with otitis media

8) Confidence 0.41 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1090599 Disease Relevance 1.16 Pain Relevance 0.26

Acute tenderness of the sacroiliac joint and elevation of the ESR were present in all.

Positive_regulation (elevation) of ESR in sacroiliac joint

9) Confidence 0.40 Published 1990 Journal Rev Med Chil Section Abstract Doc Link 2131507 Disease Relevance 0.27 Pain Relevance 0.10

Any patient with increasing back pain and an ESR greater than 52 or more weeks after surgery should be considered to have discitis until proven otherwise.

Positive_regulation (increasing) of ESR associated with discitis and backache

10) Confidence 0.40 Published 1988 Journal Spine Section Abstract Doc Link 3381147 Disease Relevance 0.53 Pain Relevance 0.10

An elevated ESR and characteristic changes on plain X-rays or bone scan are sufficient for diagnosis, but MRI is more sensitive and more specific, and it shows pathologic changes earlier.

Positive_regulation (elevated) of ESR

11) Confidence 0.40 Published 1997 Journal Childs Nerv Syst Section Abstract Doc Link 9105747 Disease Relevance 0.37 Pain Relevance 0.14

Treatment with oestrogen increased expression of ERalpha but not GPR30, while masseter inflammation increased GRP30 but not ERalpha.

Neg (not) Positive_regulation (increased) of ERalpha in masseter associated with inflammation

12) Confidence 0.36 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220308 Disease Relevance 0.49 Pain Relevance 0.80

In a yeast estrogen screen, only the lipophilic sub-fraction was able to activate the human estrogen receptor alpha, with a lower potency but comparable efficacy to that of 17 beta-estradiol.

Positive_regulation (activate) of estrogen receptor associated with potency

13) Confidence 0.34 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17689956 Disease Relevance 0.16 Pain Relevance 0.20

BACKGROUND AND PURPOSE: Estrogen receptor alpha (ESR1) gene variation is associated with a range of important estrogen-dependent characteristics, including responses of lipid profile and atherosclerotic severity to hormone replacement therapy, coronary heart disease risk, and migraine.

Positive_regulation (variation) of ESR1 in heart associated with coronary artery disease, atherosclerosis and migraine

14) Confidence 0.33 Published 2005 Journal Stroke Section Abstract Doc Link 16179580 Disease Relevance 0.51 Pain Relevance 0.13

It is well known that the classical estrogen action in neurons is to activate nuclear estrogen receptor ?

Positive_regulation (activate) of estrogen receptor in neurons

15) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016347 Disease Relevance 0.40 Pain Relevance 0.47

In other studies, ESR was elevated in 88% to 92% of osteomyelitis patients on admission, and the rate of positive test and median or mean ESR value depended on whether there patients had the acute, subacute or chronic form.[4,37] The fact that an ESR ?

Positive_regulation (elevated) of ESR associated with osteomyelitis

16) Confidence 0.28 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2588573 Disease Relevance 1.20 Pain Relevance 0.07

There was a significant i) decrease in RBC count and haemoglobin, ii) increase in WBC count and ESR of arthritic rats, when compared with the control rats.

Positive_regulation (increase) of ESR associated with arthritis

17) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.27 Pain Relevance 0.11

Laboratory findings showed increased ESR and CRP but negative HLA B52 locus.

Positive_regulation (increased) of ESR

18) Confidence 0.16 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9951823 Disease Relevance 1.10 Pain Relevance 0.18

To investigate this question, we examined where the dopamine D1-like receptor agonist, SKF 38393, altered Fos expression via estrogen receptor activation.

Positive_regulation (activation) of estrogen receptor associated with dopamine and agonist

19) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.38

ESR1 mRNA was increased in ewes treated with progesterone and estradiol plus progesterone.

Positive_regulation (increased) of ESR1

20) Confidence 0.12 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15829624 Disease Relevance 0 Pain Relevance 0.32

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