INT202801

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.37
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pin1) protein folding (Pin1) nucleus (Pin1)
cell cycle (Pin1) cytoplasm (Pin1)
Anatomy Link Frequency
T cell 2
Pin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 120 100.00 Very High Very High Very High
cva 4 69.48 Quite High
chemokine 8 45.28 Quite Low
corticosteroid 4 22.04 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
isoflurane 20 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 64 99.00 Very High Very High Very High
Hemorrhage 4 69.48 Quite High
Toxicity 16 19.12 Low Low
Graft Vs Host Disease 24 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Communicable Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell activation rapidly increased Pin1 activity leading to AUF1 isomerization and loss of mRNA binding.
Positive_regulation (increased) of Pin1
1) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.11
Here we show in vitro, using either Pin1 KO or juglone-treated splenocytes from WT rats that Pin1 activity is required to stabilize, accumulate and translate mRNAs coding for several type-1 cytokines including IFN-?
Positive_regulation (required) of Pin1 associated with targeted disruption and cytokine
2) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.12
Therefore, Pin1 is necessary for ARE mediated cytokine mRNA stabilization after T cell co-stimulation.
Positive_regulation (stabilization) of Pin1 in T cell associated with cytokine
3) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.54 Pain Relevance 0.15
Therefore, Pin1 is necessary for ARE mediated cytokine mRNA stabilization after T cell co-stimulation.
Positive_regulation (necessary) of Pin1 in T cell associated with cytokine
4) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.53 Pain Relevance 0.15

General Comments

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