INT202802

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Fkbp1a) protein folding (Fkbp1a) cytosol (Fkbp1a)
signal transduction (Fkbp1a) enzyme binding (Fkbp1a) cytoplasm (Fkbp1a)
Anatomy Link Frequency
HGF 1
Fkbp1a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 90 83.28 Quite High
antagonist 1 77.44 Quite High
Inflammation 18 5.00 Very Low Very Low Very Low
isoflurane 15 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 55 97.52 Very High Very High Very High
Targeted Disruption 48 94.96 High High
Metastasis 51 91.40 High High
Disease 5 67.96 Quite High
Death 3 58.08 Quite High
Cancer 42 43.76 Quite Low
Congenital Anomalies 3 28.16 Quite Low
Graft Vs Host Disease 18 6.32 Low Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Adhesions 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the concentrations used here neither CyA nor FKBP12 peptidyl-prolyl isomerase activities are affected [17].
Neg (neither) Regulation (affected) of FKBP12
1) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.28 Pain Relevance 0.17
Importantly, these juglone concentrations had no effect on cyclophilin A nor FKBP12 [17].
Neg (no) Regulation (effect) of FKBP12
2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0.03
Therefore, it is very unlikely that cyclophilin A nor FKBP12 were affected by juglone treatment and underlie the graft acceptance seen here.
Regulation (affected) of FKBP12
3) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0.04
MSMB, CCND1, EFNA3, FKBP and ADM, HGF are similarly regulated in mouse models and in our study [35-37].
Regulation (regulated) of FKBP in HGF
4) Confidence 0.10 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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