INT202806

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.87
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pin1) protein folding (Pin1) nucleus (Pin1)
cell cycle (Pin1) cytoplasm (Pin1)
Anatomy Link Frequency
immune cell 1
T cells 1
Pin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 150 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Inflammation 30 64.20 Quite High
fibrosis 10 59.44 Quite High
isoflurane 25 48.32 Quite Low
Multiple sclerosis 5 36.48 Quite Low
corticosteroid 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 10 98.92 Very High Very High Very High
Targeted Disruption 80 98.84 Very High Very High Very High
Recurrence 5 96.96 Very High Very High Very High
Graft Vs Host Disease 30 89.36 High High
Congenital Anomalies 5 79.60 Quite High
Adhesions 5 65.36 Quite High
INFLAMMATION 30 64.20 Quite High
Fibrosis 10 59.44 Quite High
Infection 5 53.64 Quite High
Toxicity 20 41.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with such a function, overexpression of Pin1 has been observed in many cancers, and its levels are predictive of cancer recurrence [10], [11].
Gene_expression (overexpression) of Pin1 associated with cancer and recurrence
1) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.53 Pain Relevance 0.22
and CXCL-10 within the graft and demonstration that Pin1 blockade was unable to prevent immune cell infiltration and rejection.
Gene_expression (blockade) of Pin1 in immune cell
2) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.39 Pain Relevance 0.15
Pin1 function on type 1 cytokine and chemokine expression was first evaluated in Pin1 knockout (KO) mice.
Gene_expression (expression) of Pin1 associated with targeted disruption, chemokine and cytokine
3) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.58 Pain Relevance 0.21
and IL-2 expression through Pin1 has been confirmed using T cells from KO mice.
Gene_expression (expression) of Pin1 in T cells associated with targeted disruption
4) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.29 Pain Relevance 0.07
primers for the WT pin1 allele and the forward 5?
Gene_expression (allele) of pin1
5) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.09 Pain Relevance 0

General Comments

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