INT202817

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 23
Disease Relevance 7.82
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Anatomy Link Frequency
retinas 2
brain 2
inner limiting membrane 1
blood vessels 1
glial cells 1
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 16 99.88 Very High Very High Very High
potassium channel 84 96.88 Very High Very High Very High
Inflammatory mediators 70 93.40 High High
amygdala 40 91.68 High High
Hippocampus 96 89.20 High High
Limbic system 8 87.28 High High
cerebral cortex 8 86.52 High High
palliative 8 86.20 High High
Neurotransmitter 204 83.84 Quite High
gABA 14 82.68 Quite High
Disease Link Frequency Relevance Heat
Retina Disease 350 99.40 Very High Very High Very High
Gliosis 106 99.38 Very High Very High Very High
Muscular Dystrophy 398 99.28 Very High Very High Very High
Diabetic Retinopathy 56 93.36 High High
INFLAMMATION 123 93.00 High High
Disease 71 92.20 High High
Pressure And Volume Under Development 280 90.20 High High
Stress 50 89.28 High High
Neurological Disease 16 88.24 High High
Injury 42 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the retina, Dp71 is mainly expressed in Müller cells endfeet and processes surrounding blood vessels.
Gene_expression (expressed) of Dp71 in blood vessels
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.21 Pain Relevance 0
We found that experimental retinal detachment causes alterations in water transport and impairments in fluid absorption of Müller cells, associated with a downregulation of Dp71 expression.
Gene_expression (expression) of Dp71 associated with retina disease
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.65 Pain Relevance 0
Earlier it had been shown that utrophin, a cytoskeleton protein, shares the common expression pattern of Dp71, Kir4.1, and AQP4.
Gene_expression (expression) of Dp71
3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.22 Pain Relevance 0
Our present results confirm that functional expression of Dp71 is necessary for the highly asymmetric expression of the inwardly rectifying potassium channel Kir4.1 in Müller cells, and suggest that Dp71 downregulation is one step upstream of the Kir4.1 and AQP4 channel alterations in the signaling cascade of reactive gliosis.
Gene_expression (expression) of Dp71 associated with potassium channel and gliosis
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.34 Pain Relevance 0.05
Together these data show that experimental retinal detachment-induced gliosis affects both gene and protein expression of Dp71 in Müller glial cells.
Gene_expression (expression) of Dp71 in glial cells associated with gliosis and retina disease
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.34 Pain Relevance 0
In conclusion we show here that depletion of Dp71, a cytoskeleton protein associated to the membrane, leads to physiological alterations in Müller cells similar to those observed in injured or diseased retinas; this involves a mislocation of potassium and water channels (Kir4.1 and AQP4) and a consequent dysregulation of water transport through Müller cells.
Gene_expression (depletion) of Dp71 in retinas
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.06 Pain Relevance 0
Thus suggesting that Dp71 depletion did not induce reactive Müller cells gliosis.


Gene_expression (depletion) of Dp71 associated with gliosis
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.51 Pain Relevance 0.04
Previous work on mice had shown that the deletion of Dp71 and the concomitant impairments in DAPs localization cause functio-morphological alterations of Müller glial cells, particularly in the endfoot region where Dp71 and DAPs are concentrated in wildtype retinas [15].
Gene_expression (deletion) of Dp71 in retinas
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.78 Pain Relevance 0.19
Summarizing these results, both gene and protein expression of Dp71 are strongly reduced after experimental retinal detachment in C57BL/6 mice.
Gene_expression (expression) of Dp71 associated with retina disease
9) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.30 Pain Relevance 0
In the absence of Dp71, the retinal vascular permeability was increased as compared to the controls.
Neg (absence) Gene_expression (absence) of Dp71
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.33 Pain Relevance 0.08
Here we show, for the first time, a fast decrease in gene and protein expression of Dp71 (Fig. 3).
Gene_expression (expression) of Dp71
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.16 Pain Relevance 0.06
This may indicate that generally, the mislocation of Kir4.1 channels in reactive Müller cells results from an alteration in Dp71 expression.
Gene_expression (expression) of Dp71
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.15 Pain Relevance 0.06
The clustering and precise membrane localization of Kir4.1 and AQP4 are dependent on the dystrophin gene product, Dp71 [13]–[15].
Gene_expression (product) of Dp71
13) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.11 Pain Relevance 0.14
Dp71 is detected in the inner limiting membrane, the Müller glia, and the perivascular astrocytes, while Dp140 is also present at perivascular astrocytes [158, 159].
Gene_expression (detected) of Dp71 in inner limiting membrane
14) Confidence 0.56 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.13 Pain Relevance 0.03
To determine whether retinal detachment altered the protein and mRNA expression of Dp71 in C57BL/6 mice, we performed Western blot and real-time PCR analysis at 24 hours and 7 days after surgery.
Gene_expression (expression) of Dp71 associated with retina disease
15) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.44 Pain Relevance 0
Furthermore, most DMD patients, who exhibit neurological complications, have a genetic deficiency or duplication distal to exon 44 which most likely alters expression of Dp140, Dp116, and/or Dp71 [116].
Gene_expression (expression) of Dp71 associated with muscular dystrophy
16) Confidence 0.48 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.27 Pain Relevance 0.18
Dp260 is present in the retina [119], Dp140 in the microvasculature and throughout the brain [120], Dp116 in Schwann cells of the peripheral nervous system [121], while Dp71 is highly abundant in most, if not all, brain areas examined [122].
Gene_expression (abundant) of Dp71 in brain associated with peripheral nervous system
17) Confidence 0.48 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.96 Pain Relevance 0.23
Dp260 is expressed in the retina, Dp140 in brain and kidney, Dp116 in the peripheral nervous system, and Dp71 is uniformly expressed, but most prominently present throughout the mammalian brain (reviewed in [7]; Fig. 1; Table 2).
Gene_expression (expressed) of Dp71 in kidney associated with peripheral nervous system
18) Confidence 0.43 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.11 Pain Relevance 0.05
At the ribbon synapse, Dp260, Dp140, and Dp71, as well as ?
Gene_expression (synapse) of Dp71 in synapse
19) Confidence 0.42 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.42 Pain Relevance 0
Dp71 and/or utrophin and ?
Gene_expression (/) of Dp71
20) Confidence 0.42 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0 Pain Relevance 0

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