INT202848

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.93
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Nf2) nucleolus (Nf2) plasma membrane (Nf2)
cytoskeleton (Nf2) nucleus (Nf2) protein complex (Nf2)
Anatomy Link Frequency
spinal 1
precursor cells 1
Nf2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 93 98.96 Very High Very High Very High
trigeminal ganglion 6 95.88 Very High Very High Very High
Spinal cord 12 95.20 Very High Very High Very High
fifth nerve 6 94.84 High High
metalloproteinase 28 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurofibromatosis 2 28 100.00 Very High Very High Very High
Meningioma 273 99.72 Very High Very High Very High
Metaplasia 9 99.28 Very High Very High Very High
Targeted Disruption 9 97.24 Very High Very High Very High
Paraparesis 3 97.12 Very High Very High Very High
Ganglion Cysts 6 95.88 Very High Very High Very High
Cancer 170 95.76 Very High Very High Very High
Lung Cancer 136 95.52 Very High Very High Very High
Spinal Cord Compression 3 95.20 Very High Very High Very High
Microsatellite Instability 1 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown previously that NF2 expression induces a decrease in cyclin D1 and CDK4 kinase activity, concomitant with dephosphorylation of pRB and reduced DNA synthesis (9, 28).
Gene_expression (expression) of NF2 associated with neurofibromatosis 2
1) Confidence 0.59 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.17 Pain Relevance 0.03
Osseous metaplasia is presumably induced by biallelic Nf2 inactivation in neural crest precursor cells as observed in conditional (P0) Nf2 knockout mice (4).
Gene_expression (inactivation) of Nf2 in precursor cells associated with targeted disruption and metaplasia
2) Confidence 0.57 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.26 Pain Relevance 0.26
As in our previous series, because of adCre diffusion through the CSF circulation, spinal meningiomas (n = 3) were found in adCre;Nf2flox2/flox2;Ink4a*/* mice and spinal MRI was performed in two mice presenting with paraparesis, a neurological signs suggestive of spinal cord compression (Figure 5A,C).
Gene_expression (found) of adCre;Nf2flox2/flox2 in spinal associated with meningioma, paraparesis, imagery and spinal cord
3) Confidence 0.57 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.43 Pain Relevance 0.34
The GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) RefSeq accession numbers for the genes discussed in this paper are as follows: Adcyap1r1 (NM_001025372.1), Atp2b1 (NM_026482.1), D4Ertd22e (NM_174996.2), Dnalc4 (NM_017470.1), Gtl3 (NM_008187.1), Ilf3 (NM_001042708.1), Ktn1 (NM_008477.1), Nf2 (NM_010898.2), Pitpnb (NM_019640.2), Rabggtb (NM_011231.1), Rnf14 (NM_020012.1), Samhd1 (NM_018851.2), Shc1 (NM_011368.3), Spna2 (NM_001076554.1), Timm22 (NM_019818.2), U26 (NM_173765.1), and Xpo4 (NM_020506.1).



Gene_expression (follows) of Nf2
4) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0
Use of gene-specific molecular probes has identified loss of the cyclin-dependent kinase-4 inhibitor (CDKN2A) (Prins, 1998; Illei, 2003), neurofibromatosis type 2 (NF2) (Bianchi, 1995; Sekido, 1995), p15 and p16 (Xio, 1995), p53 (Cote, 1991), and Fhit (Pylkkanen, 2004) genes in MM, supporting the role of cell cycle deregulation and inactivation of tumor suppressor genes in its pathogenesis.
Gene_expression (loss) of NF2 associated with neurofibromatosis 2, lung cancer and cancer
5) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.06 Pain Relevance 0

General Comments

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