INT202855

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Nf2) nucleolus (Nf2) plasma membrane (Nf2)
cytoskeleton (Nf2) nucleus (Nf2) protein complex (Nf2)
Nf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1 98.84 Very High Very High Very High
Calcium channel 2 75.36 Quite High
Inflammation 28 73.52 Quite High
tetrodotoxin 1 16.92 Low Low
substance P 22 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 98.98 Very High Very High Very High
Shock 2 92.80 High High
Adhesions 1 87.06 High High
Apoptosis 3 85.76 High High
INFLAMMATION 33 73.52 Quite High
Repression 67 64.44 Quite High
Death 3 63.48 Quite High
Cystitis 15 5.00 Very Low Very Low Very Low
Overactive Bladder 7 5.00 Very Low Very Low Very Low
Edema 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall NK1R-dependent genes were classified following the biological processes with which they are involved (GO anthology): apoptosis (GZMA, TNFRSF1B, TNFRSF1A, TRAF3, NOS2A, and BID); cell adhesion/hyaluronic acid binding (CD44 and AGC1); cell cycle (CCND2 and CCNG1); cell-cell signaling (FGF11 and GJA7); cytokinesis (CDC42 and KIF1B); development (FMR2); extracellular transporters & carriers (APOE); G-protein coupled receptors (GNA13 and PTGIR); growth factors (MXD1); heat shock proteins (PRNP, HSPH1, and HSPD1); immune response (BST-1, CTSW, and IL1R1); interferons (INFGR1) intracellular kinases (WBP6); intracellular transducers (MAP3K7); kinase activators & inhibitors (YWHAH); membrane channels (KCNAB1, KCNJ12, KCNQ1, and SLC30A4); nucleotide metabolism (PCSK1); oncogenes & tumor suppressors (BRCA1, MAP3K8, RET, VIL2, FLI1, MET, NF2, and VEGFR1); receptor mediated endocytosis (DAB2); receptor tyrosine kinase (EPHA2); regulation of transcription (NEUROD6); serotonin biosynthesis (YTPH1); symporters & antiporters (SLC16A1 and SLC1A1); transcription activators & repressors (FOXA1, HSF1, IER2, and NR1H2); and synaptic transmission (GRID1).


Regulation (regulation) of NF2 associated with cancer, shock, apoptosis, serotonin and adhesions
1) Confidence 0.05 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.73 Pain Relevance 0.11
Depolarization also frequently regulates splicing in genes encoding signaling and scaffold proteins (Shc1, D4Ertd22e, Samhd1, Adcyap1r1, Nf2, and Spna2).
Regulation (regulates) of Nf2
2) Confidence 0.03 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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