INT202857

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Spna2) cytoskeleton (Spna2) protein complex (Spna2)
cytoplasm (Spna2)
Anatomy Link Frequency
spines 1
Spna2 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 73.20 Quite High
Nephrotic Syndrome 16 70.56 Quite High
Renal Disease 12 56.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 53.28 Quite High
Congenital Anomalies 2 36.08 Quite Low
Stress 8 19.20 Low Low
Disease 22 14.20 Low Low
Repression 67 5.00 Very Low Very Low Very Low
Renal Failure 6 5.00 Very Low Very Low Very Low
Chronic Renal Failure 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) RefSeq accession numbers for the genes discussed in this paper are as follows: Adcyap1r1 (NM_001025372.1), Atp2b1 (NM_026482.1), D4Ertd22e (NM_174996.2), Dnalc4 (NM_017470.1), Gtl3 (NM_008187.1), Ilf3 (NM_001042708.1), Ktn1 (NM_008477.1), Nf2 (NM_010898.2), Pitpnb (NM_019640.2), Rabggtb (NM_011231.1), Rnf14 (NM_020012.1), Samhd1 (NM_018851.2), Shc1 (NM_011368.3), Spna2 (NM_001076554.1), Timm22 (NM_019818.2), U26 (NM_173765.1), and Xpo4 (NM_020506.1).



Gene_expression (follows) of Spna2
1) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0
While not all of these proteins were specifically shown to be TRPC6 binding proteins in this publication, one of the authors reports that at least eight, Spna2, Spnb2, Myh9, Myh10, Actn1, Acnt4, Dbn1, Gsn, do also specifically co-IP with TRPC6 (W.P.
Gene_expression (eight) of Spna2
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.37 Pain Relevance 0
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Spna2 in spines
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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