INT20286

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Context Info
Confidence 0.24
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 5.04
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 4
blood 2
sublingual 1
Dob2 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 9 86.40 High High
Inflammatory marker 20 85.28 High High
anesthesia 29 83.76 Quite High
cytokine 5 73.12 Quite High
Inflammatory response 22 73.04 Quite High
Dopamine 21 50.00 Quite Low
agonist 3 45.40 Quite Low
imagery 15 5.00 Very Low Very Low Very Low
Versed 11 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 130 99.56 Very High Very High Very High
Hyperglycemia 54 99.50 Very High Very High Very High
Syndrome 4 99.46 Very High Very High Very High
Hypothermia 9 98.76 Very High Very High Very High
Toxicity 4 97.20 Very High Very High Very High
Decubitus Ulcers 2 95.64 Very High Very High Very High
Hypoxia 20 93.32 High High
Heart Rate Under Development 32 90.64 High High
Pneumonia 7 90.20 High High
Wound Infection 5 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only the patients with associated HL and hyperglycemia had significantly lower values of Do2 on CPB.
Positive_regulation (values) of Do2 associated with hyperglycemia
1) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.74 Pain Relevance 0
The patient population was arranged in order of increasing peak blood glucose levels, lowest Do2, and CPB duration, and a total of 37 subgroups (75% overlapping ranges) were analyzed with respect to the HL incidence.
Positive_regulation (increasing) of Do2 in blood
2) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0 Pain Relevance 0
However, the evidence that only four patients demonstrated HL without hyperglycemia and that only patients with an HL-hyperglycemia syndrome had a significantly lower value of Do2 seems to confirm that, in our specific clinical environment, HL and hyperglycemia are linked by the causative factor of a poor Do2, leading on one side to lactate production through the anaerobic pathway and on the other to a vicious cycle of lactate production due to the poor ability to use glucose through the aerobic pathway.
Positive_regulation (value) of Do2 associated with hyperglycemia and syndrome
3) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.47 Pain Relevance 0
Stroke volume-guided fluid therapy alone was associated with much smaller increases in cardiac index and DO2 and no change in heart rate or ScvO2 (Figure 2 and Table 3).
Positive_regulation (increases) of DO2 in heart associated with stroke
4) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945135 Disease Relevance 0.42 Pain Relevance 0
In the current study, the use of a fixed low-dose inotrope infusion coupled with stroke volume-guided fluid therapy resulted in increases in heart rate and, to a lesser extent, stroke volume which in turn increased DO2 and ScvO2 to values previously associated with improved clinical outcomes [9-11].
Positive_regulation (increased) of DO2 in heart associated with stroke
5) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945135 Disease Relevance 0.45 Pain Relevance 0
Although stroke volume-guided intravenous colloid therapy led to much smaller increases in cardiac index and DO2, with no change in heart rate or ScvO2, microvascular flow was better maintained than in the CVP-guided therapy group.
Positive_regulation (increases) of DO2 in heart associated with stroke
6) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945135 Disease Relevance 0.47 Pain Relevance 0
Our principal finding is that a treatment algorithm incorporating stroke volume-guided fluid therapy and a low-dose dopexamine infusion increased global DO2 and ScvO2 in association with significant improvements in sublingual and cutaneous microvascular flow and cutaneous tissue oxygenation.
Positive_regulation (increased) of DO2 in sublingual associated with stroke
7) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945135 Disease Relevance 0.48 Pain Relevance 0.08
Control animals exhibited a spontaneous increase in mesenteric blood flow and mesenteric DO2, whereas portal lactate and portal oxygen saturation showed no significant changes.
Positive_regulation (increase) of DO2 in blood
8) Confidence 0.12 Published 2004 Journal Crit Care Section Body Doc Link PMC522840 Disease Relevance 0 Pain Relevance 0
In stable septic patients, the use of HS/hydroxyethyl-starch [25] and HS/dextran solution [16] produced transient increases in cardiac output and DO2, similar to our findings.
Positive_regulation (increases) of DO2
9) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1550924 Disease Relevance 0.35 Pain Relevance 0.04
Stroke volume-guided fluid therapy with dopexamine infusion was associated with significant increases in heart rate, cardiac index, DO2 and ScvO2.
Positive_regulation (increases) of DO2 in heart associated with stroke
10) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2945135 Disease Relevance 0.44 Pain Relevance 0
We conclude that progressive hypothermia in anesthetized patients reduces metabolic rate but does not change DO2.
Neg (not) Positive_regulation (change) of DO2 associated with hypothermia
11) Confidence 0.05 Published 1997 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 9239580 Disease Relevance 0.17 Pain Relevance 0
Of course, the observation that low values of ScVO2 and high values of peak lactates are associated with bad outcomes does not allow us to conclude that goal-directed strategies aimed to increase the DO2 during CPB may be beneficial in pediatric cardiac surgery.
Positive_regulation (increase) of DO2
12) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
Our observation only generates the hypothesis that whenever the ScVO2 is < 68% with concomitant hyperlactatemia, efforts should be applied to increase the DO2.
Positive_regulation (increase) of DO2
13) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
The change from 2LV to 1LV was associated with significant increases in cardiac index (CI) and oxygen delivery index (DO2I), whereas PaO2 and arterial and mixed venous oxygen saturation decreased.
Positive_regulation (increases) of DO2I
14) Confidence 0.01 Published 1990 Journal J Cardiothorac Anesth Section Abstract Doc Link 2132340 Disease Relevance 0.10 Pain Relevance 0.07
Since DO2I increased during 1LV to maintain the oxygen supply and demand balance, SvO2 monitoring might be useful as an early indicator in identifying high-risk patients with compromised DO2I resulting from decreased CI.
Positive_regulation (increased) of DO2I
15) Confidence 0.01 Published 1990 Journal J Cardiothorac Anesth Section Abstract Doc Link 2132340 Disease Relevance 0.15 Pain Relevance 0
There was significant increase in post-treatment levels of SBP, MAP, SVRI, VO2I, DO2I, and HVOS in both the groups [Table 4].
Positive_regulation (increase) of DO2I
16) Confidence 0.01 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC2888327 Disease Relevance 0.08 Pain Relevance 0
During extracorporal circulation an increase of DO2I and VO2I was observed.
Positive_regulation (increase) of DO2I
17) Confidence 0.00 Published 1997 Journal Langenbecks Arch Chir Section Abstract Doc Link 9324610 Disease Relevance 0.30 Pain Relevance 0.12
The increase of DO2I and VO2I in the tissues during ILP and after reperfusion was achieved by a significant increase in cardiac output while the oxygen extraction rate was not altered.
Positive_regulation (increase) of DO2I
18) Confidence 0.00 Published 1997 Journal Langenbecks Arch Chir Section Abstract Doc Link 9324610 Disease Relevance 0.42 Pain Relevance 0.10
Oxygen delivery index (DO2I) and oxygen consumption index (VO2I) were also significantly increased in the dopexamine group (DO2I: from 416 +/- 91 to 717 +/- 110 ml/m2.m2; VO2I: from 98 +/- 25 to 157 +/- 22 ml/m2.m2), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion.
Positive_regulation (increased) of DO2I
19) Confidence 0.00 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9773139 Disease Relevance 0 Pain Relevance 0
Oxygen delivery index (DO2I) and oxygen consumption index (VO2I) were also significantly increased in the dopexamine group (DO2I: from 416 +/- 91 to 717 +/- 110 ml/m2.m2; VO2I: from 98 +/- 25 to 157 +/- 22 ml/m2.m2), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion.
Positive_regulation (increased) of DO2I
20) Confidence 0.00 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9773139 Disease Relevance 0 Pain Relevance 0

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