INT202864

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 6 74.96 Quite High
cytokine 1 53.28 Quite High
Hippocampus 1 49.44 Quite Low
Glutamate receptor 3 41.44 Quite Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 67 86.36 High High
Aids-related Complex 15 82.64 Quite High
Non-genital Cutaneous Warts 3 77.76 Quite High
Depression 6 74.96 Quite High
Necrosis 1 54.20 Quite High
Cancer 1 53.84 Quite High
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Embryonal Carcinoma 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While these molecules are critical for synaptic scaling during activity blockade, additional cell autonomous mechanisms are also necessary, such as reduced CaMKIV activation and transcriptional changes (Ibata et al. 2008).
Negative_regulation (reduced) of Positive_regulation (activation) of CaMKIV
1) Confidence 0.27 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.63 Pain Relevance 0.06
This centrally located CaRRE 1 behaved similarly to an element upstream, but gave a somewhat reduced response to CaMK IV (Figure 4A, lanes 9 and 10).
Negative_regulation (reduced) of Positive_regulation (response) of CaMK IV
2) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.20 Pain Relevance 0

General Comments

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