INT202873

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.70
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
nucleus accumbens 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 47 99.68 Very High Very High Very High
Eae 8 80.72 Quite High
nMDA receptor 20 67.88 Quite High
Neurotransmitter 8 25.00 Low Low
Glutamate 4 25.00 Low Low
Calcium channel 9 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 268 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 10 94.72 High High
Anxiety Disorder 34 92.24 High High
Embryonal Carcinoma 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used recombinant adeno-associated virus (rAAV)-mediated gene transfer of a dominant-negative CaMKIV variant (rAAV-dnCaMKIV) to inhibit endogenous CaMKIV in the nucleus accumbens. rAAV-dnCaMKIV treated animals were subjected to a battery of tests including, prepulse inhibition of the acoustic startle response, open field, social interaction and anxiety-related behaviour.
Positive_regulation (transfer) of Negative_regulation (inhibit) of CaMKIV in nucleus accumbens associated with nucleus accumbens, post-traumatic stress disorder and anxiety disorder
1) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2219998 Disease Relevance 0.19 Pain Relevance 0.21
Although these other silencers may be direct targets of CaMK IV, it is possible that they serve to facilitate the CaMK IV repression by the CaRREs by weakening the overall splicing of E21.
Positive_regulation (facilitate) of Negative_regulation (repression) of CaMK IV associated with repression
2) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.51 Pain Relevance 0
In addition to the CaRRE 1 motif, we identified a novel functional element GUGGUAGA in E21 that was also able to mediate the CaMK IV–induced repression.
Positive_regulation (mediate) of Negative_regulation (repression) of CaMK IV associated with repression
3) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.34 Pain Relevance 0
Thus, either exonic CaRRE can be sufficient for CaMK IV–induced repression.
Positive_regulation (sufficient) of Negative_regulation (repression) of CaMK IV associated with repression
4) Confidence 0.23 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1790950 Disease Relevance 0.28 Pain Relevance 0.10
Both elements mediate CaMK IV–inducible repression, but the element from E21, which contains a UAGG, is stronger (Figure 4C).
Positive_regulation (mediate) of Negative_regulation (repression) of CaMK IV associated with repression
5) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.38 Pain Relevance 0

General Comments

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