INT20289

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Context Info
Confidence 0.26
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.23
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
monocytes 2
lymphocytes 2
NK cells 2
T cells 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 156 100.00 Very High Very High Very High
anesthesia 6 99.34 Very High Very High Very High
Opioid 6 98.92 Very High Very High Very High
noradrenaline 3 96.60 Very High Very High Very High
Inflammation 36 94.40 High High
opioid receptor 6 91.56 High High
Enkephalin 1 89.08 High High
dexamethasone 4 83.44 Quite High
Delta opioid receptors 1 75.00 Quite High
cINOD 4 73.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 42 94.40 High High
Influenza Virus Infection 11 90.32 High High
Cancer 101 75.00 Quite High
Infection 30 67.84 Quite High
Stress 9 59.56 Quite High
Immunization 3 54.56 Quite High
Hepatitis 2 52.64 Quite High
Bacterial Infection 3 52.56 Quite High
Wound Infection 2 50.32 Quite High
Thrombosis 2 40.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data show that Tenoxicam inhibits the neutrophil and monocyte functional chemotactic response in vitro, and to some extent in vivo for monocytes, but has no effect on the expression of IL-2 receptors or IL-1 release.
Neg (no) Regulation (effect) of Localization (release) of IL-2 in monocytes
1) Confidence 0.26 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2133022 Disease Relevance 0.24 Pain Relevance 0.16
HMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Regulation (sensitive) of Localization (lysis) of IL-2 in NK cells
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.07 Pain Relevance 0
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Regulation (regulated) of Localization (secretion) of IL-2 associated with anesthesia and cytokine
3) Confidence 0.13 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.17 Pain Relevance 0.32
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Regulation (regulated) of Localization (secretion) of IL-2 associated with anesthesia and cytokine
4) Confidence 0.13 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.12 Pain Relevance 0.32
In this context, mainly the use of IL-2 and IL-7 has been considered (Sin et al 2000).
Regulation (considered) of Localization (use) of IL-2
5) Confidence 0.08 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.50 Pain Relevance 0.04
These results advance the molecular understanding of opioid effects on lymphocytes, and in addition, demonstrate regulation of IL-2 synthesis and secretion by the novel mechanism of receptor-mediated AP-1 induction.
Regulation (regulation) of Localization (secretion) of IL-2 in lymphocytes associated with opioid
6) Confidence 0.04 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9548483 Disease Relevance 0.06 Pain Relevance 0.55
GM-CSF stimulated the secretion of IL-1 alpha, IL-1 beta and TNF gamma, but had no influence on the secretion of IL-2, IFN alpha and IFN gamma.
Neg (no) Regulation (influence) of Localization (secretion) of IL-2
7) Confidence 0.01 Published 1997 Journal Eur. J. Cancer Section Abstract Doc Link 9389931 Disease Relevance 0.07 Pain Relevance 0.67
The effect of deltorphin and DAME on secretion of the T cell growth factor, IL-2, was determined by ELISA analysis of supernatants obtained from CD4+ T cells after 48-hr culture.
Regulation (effect) of Localization (secretion) of cell growth factor in T cells
8) Confidence 0.01 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791081 Disease Relevance 0 Pain Relevance 0.18

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