INT202906

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 17
Disease Relevance 5.65
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Atf3) nucleus (Atf3) DNA binding (Atf3)
Anatomy Link Frequency
neurons 6
Schwann cells 6
nerve 2
motor neurons 2
Atf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 161 99.88 Very High Very High Very High
Nerve growth factor 32 96.24 Very High Very High Very High
substance P 53 95.72 Very High Very High Very High
trigeminal ganglion 27 85.56 High High
Sciatic nerve 272 78.68 Quite High
trk B 9 75.76 Quite High
Pain 32 50.52 Quite High
Neuropeptide 18 50.00 Quite Low
unmyelinated 16 45.04 Quite Low
dorsal root ganglion 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 354 99.76 Very High Very High Very High
Apoptosis 32 89.28 High High
Nervous System Injury 88 86.40 High High
Shock 16 86.00 High High
Ganglion Cysts 81 85.56 High High
Adhesions 64 85.08 High High
Stress 16 83.88 Quite High
Pain 32 50.52 Quite High
Leukemia 16 48.24 Quite Low
INFLAMMATION 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of Schwann cells and neurons in the spinal cord that express ATF3 declines over time if nerve regeneration is prevented [14,16,17], although some sensory neurons may express ATF3 for at least 140 days after injury [16].
Negative_regulation (declines) of ATF3 in Schwann cells associated with injury and spinal cord
1) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.60 Pain Relevance 0.05
Progression of axonal outgrowth into the distal nerve segment after a nerve crush decreases the number of ATF3 stained motor and sensory neurons both with time and with reinnervation indicating a complex regulation [16].
Negative_regulation (number) of ATF3 in nerve
2) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.08 Pain Relevance 0
If the present data is compared with previous reports of the decline of ATF3 expression after injury [16], one may suggest that a neuron or a Schwann cell that has lost ATF3 will probably not properly recover their ability to express ATF3 after an additional injury with a diminution of supporting nerve regeneration.


Negative_regulation (lost) of ATF3 in neuron associated with injury
3) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.87 Pain Relevance 0
However, the latter three groups were not different from each other with respect to number of ATF3 stained motor neurons.


Negative_regulation (number) of ATF3 in motor neurons
4) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.16 Pain Relevance 0.14
In the spinal cord, the number of ATF3 stained motor neurons decreased significantly between immediate repair and a repair with a delay of 30 days.
Negative_regulation (number) of ATF3 in motor neurons associated with spinal cord
5) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.10
ATF3 stained Schwann cells were also seen where there were no regenerating fibers in the distal nerve segment, signifying that contact with regenerating nerve fibers is not completely responsible for the decline in ATF3 in Schwann cells [16].
Negative_regulation (decline) of ATF3 in Schwann cells
6) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.32 Pain Relevance 0.05
Regeneration distances correlate to the decline of both the number of ATF3 stained neurons and Schwann cells over time.
Negative_regulation (number) of ATF3 in Schwann cells
7) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.77 Pain Relevance 0
The reduction of ATF3 stained neurons and Schwann cells correlated to axonal outgrowth.
Negative_regulation (reduction) of ATF3 in Schwann cells
8) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.09 Pain Relevance 0
Regeneration distances over time correlated to number of ATF3 stained neurons and Schwann cells.
Negative_regulation (number) of ATF3 in neurons
9) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2556676 Disease Relevance 0.24 Pain Relevance 0.04
A nerve repair 30 days after injury leads to a reduction in the number of ATF3 stained Schwann cells in the distal nerve [14].
Negative_regulation (reduction) of ATF3 in nerve associated with injury
10) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.57 Pain Relevance 0.05
In addition, inhibition of JNK, and thereby ATF3, reduces outgrowth of sensory axons [12].
Negative_regulation (inhibition) of ATF3
11) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.07
Schwann cells; [14]) in the injured nerve trunk showed a decline in ATF3 response after transection and delayed nerve repair.
Negative_regulation (decline) of ATF3 in Schwann cells
12) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.09 Pain Relevance 0
After tooth extraction, some PGP-9.5 immunopositive neurons appeared to be immuno­positive for ATF3 (Fig. 1q, r).
Negative_regulation (positive) of ATF3 in neurons
13) Confidence 0.35 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.17 Pain Relevance 0.59
The number of Schwann cells and neurons in the spinal cord that express ATF3 declines over time if nerve regeneration is prevented [14,16,17], although some sensory neurons may express ATF3 for at least 140 days after injury [16].
Negative_regulation (declines) of ATF3 in neurons associated with injury and spinal cord
14) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.60 Pain Relevance 0.05
Regeneration distances correlate to the decline of both the number of ATF3 stained neurons and Schwann cells over time.
Negative_regulation (number) of ATF3 in neurons
15) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.77 Pain Relevance 0
Regeneration distances over time correlated to number of ATF3 stained neurons and Schwann cells.
Negative_regulation (number) of ATF3 in Schwann cells
16) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2556676 Disease Relevance 0.24 Pain Relevance 0.04
The reduction of ATF3 stained neurons and Schwann cells correlated to axonal outgrowth.
Negative_regulation (reduction) of ATF3 in neurons
17) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.09 Pain Relevance 0

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