INT202921

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.60
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Efemp2) proteinaceous extracellular matrix (Efemp2)
Anatomy Link Frequency
motor neuron 4
muscles 2
endothelium 2
Efemp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 50.32 Quite High
Hippocampus 2 50.20 Quite High
imagery 15 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 18 99.28 Very High Very High Very High
Motor Neuron Diseases 21 96.84 Very High Very High Very High
Targeted Disruption 68 85.12 High High
Congenital Anomalies 5 75.00 Quite High
Intellectual Impairment 2 71.52 Quite High
Syndrome 2 69.24 Quite High
Marfan Syndrome 2 53.12 Quite High
Mixed Connective Tissue Disorder 2 51.60 Quite High
Aneurism 10 44.48 Quite Low
Disease 15 42.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another difference between the two strains was that the endothelium was often sloughed in the fibulin-4+/?
Negative_regulation (sloughed) of Gene_expression (/) of fibulin-4 in endothelium associated with sprains and strains
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.10 Pain Relevance 0
In the present study, arterial pathologies in fibulin-4+/?
Negative_regulation (pathologies) of Gene_expression (/) of fibulin-4
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.39 Pain Relevance 0.03
Using behavioral tests, Miller et al [15] reached a similar conclusion after reducing expression of mutant protein in muscles of mice that ubiquitously express SOD1G93A.
Negative_regulation (reducing) of Gene_expression (expression) of mutant protein in muscles
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.37 Pain Relevance 0.03
The reduction was incomplete, however, leaving open the possibility that reduced expression of mutant protein in muscle or a reduced number of expressing fibers is sufficient to cause the motor neuron disease phenotype.
Negative_regulation (reduced) of Gene_expression (expression) of mutant protein in motor neuron associated with motor neuron diseases
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.38 Pain Relevance 0
The reduction was incomplete, however, leaving open the possibility that reduced expression of mutant protein in muscle or a reduced number of expressing fibers is sufficient to cause the motor neuron disease phenotype.
Negative_regulation (reduced) of Gene_expression (expression) of mutant protein in motor neuron associated with motor neuron diseases
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.38 Pain Relevance 0

General Comments

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