INT202935

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 7.53
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SERPINF1) extracellular space (SERPINF1) aging (SERPINF1)
extracellular region (SERPINF1)
Anatomy Link Frequency
epithelium 4
body 3
platelet 2
fibroblasts 2
plasma 1
SERPINF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 27 99.68 Very High Very High Very High
chemokine 11 99.26 Very High Very High Very High
cytokine 38 99.04 Very High Very High Very High
Nicotine 181 97.20 Very High Very High Very High
Inflammation 138 89.00 High High
agonist 12 81.04 Quite High
metalloproteinase 8 80.04 Quite High
Multiple sclerosis 30 77.96 Quite High
Dismenorea 10 76.16 Quite High
imagery 21 21.52 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 29 99.88 Very High Very High Very High
Wound Healing 17 99.76 Very High Very High Very High
Central Nervous System Disease 25 99.68 Very High Very High Very High
Neuromyelitis Optica 405 99.60 Very High Very High Very High
Adhesions 22 99.00 Very High Very High Very High
Choroideremia 498 98.96 Very High Very High Very High
Targeted Disruption 12 90.88 High High
INFLAMMATION 148 89.00 High High
Neurological Disease 10 84.48 Quite High
Premature Birth 70 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PEDF is a potent inhibitor of angiogenesis in the eye [39] and has also been detected in plasma and serum [40, 41].
Gene_expression (detected) of PEDF in plasma
1) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.04
Pigment epithelium-derived factor (PEDF), also called SERPINF1, is a neuroprotective and anti-angiogenic factor [46] that is widely expressed in the CNS, including the retina, and in most tissues of the body.
Gene_expression (expressed) of SERPINF1 in body associated with central nervous system
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.26 Pain Relevance 0.14
-glycoprotein (A1BG), DBP, fibrinogen gamma chain (FGG), pigment epithelium-derived factor (PEDF), apolipoprotein A-IV (ApoA-IV), apolipoprotein E (ApoE), and transthyretin (TTR) were downregulated in the NMO group in comparison to the control group.
Gene_expression (chain) of epithelium-derived factor in epithelium associated with neuromyelitis optica and disorder of lipid metabolism
3) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.58 Pain Relevance 0
-glycoprotein (A1BG), DBP, fibrinogen gamma chain (FGG), pigment epithelium-derived factor (PEDF), apolipoprotein A-IV (ApoA-IV), apolipoprotein E (ApoE), and transthyretin (TTR) were downregulated in the NMO group in comparison to the control group.
Gene_expression (chain) of PEDF in epithelium associated with neuromyelitis optica and disorder of lipid metabolism
4) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.58 Pain Relevance 0
The presence of PEDF and involucrin, two proteins not previously reported in platelet releasate, was confirmed by western blotting.
Gene_expression (presence) of PEDF in platelet
5) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2846341 Disease Relevance 0.20 Pain Relevance 0
The presence of two novel platelet proteins, PEDF and involucrin (see Supplementary Table 1 for full details), was confirmed by immunoblotting (Figure 5).
Gene_expression (presence) of PEDF in platelet
6) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0.06 Pain Relevance 0.04
Previous studies have identified PEDF at 50?
Gene_expression (identified) of PEDF
7) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.03
Pigment epithelium-derived factor (PEDF), also called SERPINF1, is a neuroprotective and anti-angiogenic factor [46] that is widely expressed in the CNS, including the retina, and in most tissues of the body.
Gene_expression (expressed) of PEDF in body associated with central nervous system
8) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.27 Pain Relevance 0.15
Pigment epithelium-derived factor (PEDF), also called SERPINF1, is a neuroprotective and anti-angiogenic factor [46] that is widely expressed in the CNS, including the retina, and in most tissues of the body.
Gene_expression (expressed) of epithelium-derived factor in body associated with central nervous system
9) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.33 Pain Relevance 0.15
All proteins found differentially down-regulated in amniotic fluid expressing the Q-profile (pigment epithelium-derived factor [PEDF] and alpha-1 antitrypsin) were members of serpin superfamily.
Gene_expression (expressing) of PEDF in epithelium
10) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.39 Pain Relevance 0.23
All proteins found differentially down-regulated in amniotic fluid expressing the Q-profile (pigment epithelium-derived factor [PEDF] and alpha-1 antitrypsin) were members of serpin superfamily.
Gene_expression (expressing) of epithelium-derived factor in epithelium
11) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.39 Pain Relevance 0.22
In contrast, fibroblasts from CHM patients, when compared to normal controls, secreted significantly lower levels of MCP-1, PEDF, TNF-alpha, FGF and IL-8.
Gene_expression (levels) of PEDF in fibroblasts associated with choroideremia
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.62 Pain Relevance 0
Levels of IL-8, MCP-1, TNF-alpha, FGF and PEDF factors were significantly higher in samples collected from the control cells (p<0.005), and levels of VEGF and EGF did not change significantly.
Gene_expression (Levels) of PEDF
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.71 Pain Relevance 0.09
Levels of different cytokine/chemokines and growth factors: IL8, MCP-1, TNF alpha, epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and PEDF were measured in aliquots of conditioned media collected from primary fibroblasts of CHM and age matched control patients by commercial technology (SearchLight, Aushon BioSystems, Inc, Woburb, MA).
Gene_expression (alpha) of PEDF in fibroblasts associated with chemokine, choroideremia and cytokine
14) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.15 Pain Relevance 0.15
Repeated measures ANOVA indicated a significant effect of lever (F1,64?
Gene_expression (effect) of F1 in lever
15) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794142 Disease Relevance 0 Pain Relevance 0.31

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