INT202940

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 16.43
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AMD1) small molecule metabolic process (AMD1) lyase activity (AMD1)
cellular nitrogen compound metabolic process (AMD1)
Anatomy Link Frequency
eyes 1
blood 1
body 1
AMD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 64 97.88 Very High Very High Very High
spinal inflammation 1 95.80 Very High Very High Very High
Multiple sclerosis 1 74.56 Quite High
depression 4 58.64 Quite High
Neuritis 1 52.64 Quite High
iatrogenic 1 28.08 Quite Low
imagery 8 9.48 Low Low
cva 32 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 1047 100.00 Very High Very High Very High
Glaucoma 42 100.00 Very High Very High Very High
Cardiovascular Disease 5 100.00 Very High Very High Very High
Cataract 44 99.40 Very High Very High Very High
Diabetes Mellitus 154 99.28 Very High Very High Very High
Scotoma 23 99.04 Very High Very High Very High
INFLAMMATION 64 97.88 Very High Very High Very High
Adverse Drug Reaction 5 96.48 Very High Very High Very High
Low Back Pain 1 95.80 Very High Very High Very High
Hypersensitivity 5 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Melbourne Visual Impairment Project (VIP) showed that, whilst there was a positive association with the actual prevalence of AMD and cholesterol-lowering medication (perhaps explained by a possible association between cardiovascular disease and AMD), participants on these medications were almost four times less likely to experience progression than those not taking medication (3.6% vs 13%), although this difference was not significant (McCarty et al 2001a, 2001b).
AMD Binding (association) of associated with cardiovascular disease and age-related macular degeneration
1) Confidence 0.41 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.94 Pain Relevance 0.07
The association between AMD and the use of cholesterol-lowering medications has been examined by a number of clinical studies, and there is a growing body of evidence that such an association exists, and it is inverse.
AMD Binding (association) of in body associated with age-related macular degeneration
2) Confidence 0.41 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.86 Pain Relevance 0.10
AMD eligible criteria were: 1) high-risk feature of early AMD in both eyes; 2) >1 large soft druse(>125 ?
AMD Binding (criteria) of in eyes associated with age-related macular degeneration
3) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.27 Pain Relevance 0
In our preliminary studies, visual function tests showed high sensitivity and specificity for AMD, eg, 93% of the AMD participants had at least one recovery parameter that was abnormal.
AMD Binding (specificity) of associated with age-related macular degeneration
4) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.26 Pain Relevance 0
The Melbourne Visual Impairment Project (VIP) showed that, whilst there was a positive association with the actual prevalence of AMD and cholesterol-lowering medication (perhaps explained by a possible association between cardiovascular disease and AMD), participants on these medications were almost four times less likely to experience progression than those not taking medication (3.6% vs 13%), although this difference was not significant (McCarty et al 2001a, 2001b).
AMD Binding (association) of associated with cardiovascular disease and age-related macular degeneration
5) Confidence 0.30 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.94 Pain Relevance 0.07
Treatment of neovascular AMD in patients with diabetes
AMD Binding (Treatment) of associated with diabetes mellitus and age-related macular degeneration
6) Confidence 0.25 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 2.08 Pain Relevance 0.07
Treatment of neovascular AMD in patients with diabetes
AMD Binding (Treatment) of associated with diabetes mellitus and age-related macular degeneration
7) Confidence 0.25 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.28 Pain Relevance 0
Complement pathway dysregulation was a novel, unexpected association with AMD.
AMD Binding (association) of associated with age-related macular degeneration
8) Confidence 0.16 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717811 Disease Relevance 1.12 Pain Relevance 0.13
The United States Food and Drug Administration (FDA) approved pegaptanib sodium (Macugen TM , OSI-Eyetech, New York, NY) that binds the VEGF 165 isoform in December 2004 for treatment of all neovascular AMD regardless of lesion composition.
AMD Binding (binds) of associated with age-related macular degeneration
9) Confidence 0.09 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.49 Pain Relevance 0
The neovascular form of AMD accounts for 10 to 20% of the total patients with macular degeneration and is associated with the formation of neovascular membranes below the retina that release blood and fluid distorting central vision.2 Eventually, these neovascular lesions result in a scar leading to irreversible central vision loss.
AMD Binding (associated) of in blood associated with cicatrix and age-related macular degeneration
10) Confidence 0.09 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.77 Pain Relevance 0.03
Finally, AMD and glaucoma are both associated with the occurrence of visual field defects but differ in the pathology.
AMD Binding (associated) of associated with scotoma, glaucoma and age-related macular degeneration
11) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794168 Disease Relevance 0.96 Pain Relevance 0.09
The TIMP3 mutation in SFD has not correlated with AMD [66,130], although distribution of the TIMP3 enzyme product in the AMD Bruch's membrane is significantly higher than age-matched controls, remains in active form, and is associated with drusen patches [76].
AMD Binding (correlated) of associated with ocular toxicity (including many sub-types) and age-related macular degeneration
12) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.31 Pain Relevance 0
Correction of gene defects in other retinal disorders such as AMD already associated with multiple genes, polymorphisms, and environmental factors, however, is unlikely using the iPSC approach, and in this case the usefulness of iPSC technology will mainly rely on the development of screening tools that will enable identification of individuals with high-risk of advanced AMD prior to retinal degeneration.


AMD Binding (associated) of associated with age-related macular degeneration and retina disease
13) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.49 Pain Relevance 0
Susceptibility loci (chromosome 1, 5, 9, 10, and 17) [101–103] and candidate genes that appear to play a role have been identified [104–108], some correlating with AMD pathology more strongly than others; more than 100 different proteins are associated with AMD deposits [108].
AMD Binding (associated) of associated with age-related macular degeneration
14) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.37 Pain Relevance 0
Y402H is not a primary indicator in Japanese patients, however [119], nor in the Chinese population in which this polymorphism is associated specifically with neovascular AMD [120].
AMD Binding (associated) of associated with age-related macular degeneration
15) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.07 Pain Relevance 0
Surgery for neovascular AMD
AMD Binding (Surgery) of associated with age-related macular degeneration
16) Confidence 0.02 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698673 Disease Relevance 1.22 Pain Relevance 0

General Comments

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