INT202976

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 7 Disease Relevance 9.73 Pain Relevance 3.78

extracellular region (STC2) cell-cell signaling (STC2)

STC2 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 952 100.00 cerebral cortex 28 5.00 epidural 14 5.00 agonist 14 5.00 anesthesia 7 5.00 ischemia 7 5.00 Deep tissue 7 5.00 Dopamine 7 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 931 100.00 Injury 84 98.64 Cerebral Hypoxia 35 98.44 Brain Injury 182 95.28 Sleep Disorders 21 94.28 Emergencies 7 87.44 Brain Death 7 72.92 Coma 28 72.04 Disease 7 47.64 Pressure Volume 2 Under Development 35 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Surviving and good neurological outcome patients have increased CPP, StcO2, and BIS and decreased ICP and CAP Index (Table 2).

Positive_regulation (increased) of StcO2 associated with cva

1) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.79 Pain Relevance 0.35

Increased BIS is associated with increased StcO2.

Positive_regulation (increased) of StcO2

2) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.55

Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.

Positive_regulation (increased) of StcO2 associated with cva

3) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.19 Pain Relevance 0.57

Good neurological outcome patients also have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.

Positive_regulation (increased) of StcO2 associated with cva

4) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.27 Pain Relevance 0.60

Other patients who may benefit from BIS and StcO2 monitoring without ICP monitoring are blunt trauma patients with intracranial hemorrhage, GCS score 9 to 12, and the need for mechanical ventilation and sedation.

Positive_regulation (monitoring) of StcO2 associated with injury, cva and sleep disorders

5) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.88 Pain Relevance 0.54

Variation in StcO2 and BIS are associated with changes in ICP and CPP.

Positive_regulation (Variation) of StcO2 associated with cva

6) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.33 Pain Relevance 0.60

With increased ICP or decreased CPP, StcO2 is reduced.

Positive_regulation (increased) of StcO2 associated with cva

7) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.64 Pain Relevance 0.57

General Comments

This test has worked.