INT20303
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
CYP2E1 is developmentally regulated, under liver-specific control, and undergoes substrate-induced protein stabilization. | |||||||||||||||
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Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase. | |||||||||||||||
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Three weeks later, the rats were either sacrificed for an in vitro metabolism study or challenged with 0.50 g/kg CCl(4) p.o. or 0.75 g/kg APAP i.p.TRZ at 100 and 500 mg/kg/rat increased the CYP3A level as well as the testosterone 6beta-hydroxylation activities in liver microsomes, but did not affect CYP2E1. | |||||||||||||||
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In adult animals, CYP2E1 is posttranscriptionally regulated through mRNA and protein stabilization. | |||||||||||||||
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To determine if this increase in ROS production was related to AAP-induced CYP2E1 activity and caused a decrease in GSH levels, we studied the effect of NAC and of the CYP2E1 inhibitor TTD. | |||||||||||||||
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The role of diet and ethanol induction and inhibition on CYP2E1, the enzyme of greatest interest for acetaminophen is multifaceted. | |||||||||||||||
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The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats. | |||||||||||||||
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The mechanism of regulation CYP2E1 and its role in acetaminophen toxicity will be discussed. | |||||||||||||||
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For example, a previous report showed changes in male rat hepatic Cyp2e1 activity between 3 and 18 months of age despite the relative stasis of mRNA and protein levels [44]. | |||||||||||||||
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Although probably best recognized as an inhibitor of drug metabolism, isoniazid has a biphasic effect of inhibition-induction on one cytochrome P450 isozyme, CYP2E1, which partially explains the interaction with acetaminophen and increased risk of hepatotoxicity. | |||||||||||||||
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An evaluation of the effects of posaconazole on the various CYP450 enzymes demonstrated an inhibitory effect on CYP3A4 activity, but no influence on the activity of the other isoenzymes (CYP1A2, CYP2C8/9, CYP2D6 or CYP2E1) (Wexler et al 2004). | |||||||||||||||
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