INT203035

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.97
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdcd1lg2)
Anatomy Link Frequency
macrophages 1
B-cells 1
dendritic cells 1
Pdcd1lg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 114 99.70 Very High Very High Very High
rheumatoid arthritis 24 87.04 High High
spinal inflammation 90 83.28 Quite High
tolerance 14 53.20 Quite High
abatacept 3 39.24 Quite Low
cytokine 10 19.20 Low Low
Hippocampus 15 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 119 99.70 Very High Very High Very High
Autoimmune Disease 6 91.52 High High
Dyskinesias 1 87.60 High High
Rheumatoid Arthritis 24 87.04 High High
Systemic Lupus Erythematosus 30 86.52 High High
Seronegative Spondarthritis 102 83.28 Quite High
Death 21 82.00 Quite High
Congenital Anomalies 43 73.68 Quite High
Dilated Cardiomyopathy 2 65.44 Quite High
Syndrome 6 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its two ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC) are also constitutively expressed on a large panel of non-lymphoid organs, suggesting a peripheral regulation of self-reactive T- or B-cells.
Gene_expression (expressed) of PD-L2 in B-cells
1) Confidence 0.58 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.13 Pain Relevance 0
The ligands for PD-1 have been identified as PD-L1 (B7-H1), which is expressed in all haemopoietic cells as well as in many non-haemopoietic tissues, and PD-L2 (B7-DC), which is expressed primarily on dendritic cells and macrophages [14,16,18,19].
Gene_expression (expressed) of PD-L2 in macrophages
2) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.73 Pain Relevance 0.35
Microarrays reflect inflammation and increased expression of CD36 and PD1L, GFAP, ubiquitin ligase, and C1q
Gene_expression (expression) of PD1L associated with inflammation
3) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.38 Pain Relevance 0.05
The ligands for PD-1 have been identified as PD-L1 (B7-H1), which is expressed in all haemopoietic cells as well as in many non-haemopoietic tissues, and PD-L2 (B7-DC), which is expressed primarily on dendritic cells and macrophages [14,16,18,19].
Gene_expression (expressed) of PD-L2 in dendritic cells
4) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.73 Pain Relevance 0.35

General Comments

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