INT20304

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.50
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
mononuclear cells 4
liver 3
hepatocyte 1
Brain 1
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 16 99.66 Very High Very High Very High
Nicotine 9 98.72 Very High Very High Very High
Hippocampus 2 96.64 Very High Very High Very High
Paracetamol 16 96.56 Very High Very High Very High
lidocaine 1 92.20 High High
Analgesic 3 84.04 Quite High
halothane 1 83.44 Quite High
Chronic pancreatitis 2 78.40 Quite High
alcohol 2 75.00 Quite High
fibrosis 2 61.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 98.28 Very High Very High Very High
Urological Neuroanatomy 2 96.00 Very High Very High Very High
Death 5 95.12 Very High Very High Very High
Stress 2 87.28 High High
Pancreatitis 4 86.60 High High
Acute Liver Failure 3 82.00 Quite High
Toxicity 3 81.84 Quite High
Glioma 2 75.00 Quite High
Alcoholic Pancreatitis 3 74.96 Quite High
Nicotine Addiction 4 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription of the CYP2E1 gene is primarily due to the binding of the hepatocyte-specific transcription factor HNF-1 to a segment of DNA just upstream of the start site for RNA synthesis.
Transcription (Transcription) of CYP2E1 gene in hepatocyte
1) Confidence 0.70 Published 1990 Journal Int. Symp. Princess Takamatsu Cancer Res. Fund Section Abstract Doc Link 2134674 Disease Relevance 0 Pain Relevance 0.21
Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1).
Transcription (levels) of CYP2E1 in liver
2) Confidence 0.65 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1).
Transcription (levels) of CYP2E1 in liver
3) Confidence 0.65 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
Good correlations were observed between mRNA expression and enzyme activity of CYP2C11, CYP2E1, CYP3A2 and CYP1A2 in livers of rats given various doses of CCl(4).
Transcription (expression) of CYP2E1 in livers
4) Confidence 0.61 Published 2004 Journal Int J Pharm Section Abstract Doc Link 14706259 Disease Relevance 0.16 Pain Relevance 0.09
Brain CYP2E1 mRNA levels did not increase after chronic nicotine treatment, suggesting nontranscriptional regulation.
Transcription (levels) of CYP2E1 in Brain associated with nicotine
5) Confidence 0.53 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.62 Pain Relevance 0.52
RESULTS: There was a significant correlation between level of CYP2E1 mRNA in mononuclear cells and the area under the plasma concentration-time curve of plasma inorganic fluoride from the beginning of sevoflurane administration to infinity in uninduced and uninhibited patients (r2 = 0.56; P < 0.01).
Transcription (level) of CYP2E1 in mononuclear cells
6) Confidence 0.52 Published 2000 Journal Anesthesiology Section Body Doc Link 10839917 Disease Relevance 0 Pain Relevance 0
In this study, the authors evaluated the relation between plasma concentration of inorganic fluoride after sevoflurane anesthesia and CYP2E1 mRNA level in mononuclear cells.
Transcription (level) of CYP2E1 in mononuclear cells associated with anesthesia
7) Confidence 0.52 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10839917 Disease Relevance 0 Pain Relevance 0.35
Levels of CYP2E1 mRNA in mononuclear cells were measured by competitive reverse transcription polymerase chain reaction with a specific primer and competitor for CYP2E1 mRNA.
Transcription (Levels) of CYP2E1 in mononuclear cells
8) Confidence 0.52 Published 2000 Journal Anesthesiology Section Body Doc Link 10839917 Disease Relevance 0 Pain Relevance 0
Area under the plasma concentration-time curve of inorganic fluoride following sevoflurane anesthesia correlates with CYP2E1 mRNA level in mononuclear cells.
Transcription (level) of CYP2E1 in mononuclear cells associated with anesthesia
9) Confidence 0.52 Published 2000 Journal Anesthesiology Section Title Doc Link 10839917 Disease Relevance 0 Pain Relevance 0.37
There were no significant differences in the distribution of ADH3, ALDH2, and CYP2E1 genotypes between P+ and P- patients.
Transcription (distribution) of CYP2E1
10) Confidence 0.38 Published 1996 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 8986224 Disease Relevance 0.83 Pain Relevance 0.28
Pretreatment with YH439, an inhibitor of CYP2E1 gene transcription, markedly reduced CYP2E1 mRNA, protein content, and activity, as well as the rate of AAP-induced JNK activation and cell death.
Transcription (transcription) of CYP2E1 gene associated with paracetamol and death
11) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562448 Disease Relevance 0.89 Pain Relevance 0.75

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