INT203046

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.97
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDCD1, CD274) plasma membrane (PDCD1, CD274) cell proliferation (CD274)
signal transducer activity (PDCD1)
Anatomy Link Frequency
lymphocyte 2
B cells 1
PDCD1 (Homo sapiens)
CD274 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 100.00 Very High Very High Very High
tolerance 3 94.36 High High
rheumatoid arthritis 15 79.60 Quite High
Multiple sclerosis 2 74.80 Quite High
spinal inflammation 49 72.40 Quite High
Central nervous system 2 49.28 Quite Low
Inflammation 2 29.72 Quite Low
psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 85.84 High High
Autoimmune Disease 13 85.52 High High
Apoptosis 9 85.40 High High
Systemic Lupus Erythematosus 19 83.12 Quite High
Syndrome 45 80.96 Quite High
Rheumatoid Arthritis 17 79.60 Quite High
Diabetes Mellitus 2 76.48 Quite High
Disease 22 76.32 Quite High
Demyelinating Disease 2 74.80 Quite High
Low Back Pain 4 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an immunoinhibitory receptor, PD-1 has been shown to inhibit lymphocyte activation and cytokine production after interacting with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC) [10-12].
PD-1 Binding (interacting) of B7-H1 in lymphocyte associated with cytokine
1) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.61 Pain Relevance 0.20
As an immunoinhibitory receptor, PD-1 has been shown to inhibit lymphocyte activation and cytokine production after interacting with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC) [10-12].
PD-1 Binding (interacting) of PD-L1 in lymphocyte associated with cytokine
2) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.56 Pain Relevance 0.20
The cytoplasmic immunoreceptor tyrosine-based inhibitory motif of PD-1 was activated by an interaction between PD-1 and its corresponding ligands, PDL-1 (B7-H1) and PDL-2 (B7-DC) [15,16], which induces the inhibitory signal to inhibit the proliferation of T and B cells to maintain peripheral tolerance [14-16].
PD-1 Binding (interaction) of PDL-1 in B cells associated with tolerance
3) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.80 Pain Relevance 0.29

General Comments

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