INT203047

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 21
Disease Relevance 12.32
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD274) signal transduction (CD274) plasma membrane (CD274)
Anatomy Link Frequency
PDL-1 4
NK cells 3
T-cell 2
macrophages 1
dendritic cells 1
CD274 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 60 98.60 Very High Very High Very High
rheumatoid arthritis 28 91.40 High High
Inflammation 251 90.40 High High
spinal inflammation 90 87.64 High High
chemokine 47 81.12 Quite High
COX2 80 68.76 Quite High
cytokine 182 68.72 Quite High
dexamethasone 17 54.32 Quite High
tolerance 9 44.48 Quite Low
Central nervous system 25 10.68 Low Low
Disease Link Frequency Relevance Heat
Glioblastoma 38 100.00 Very High Very High Very High
Adenocarcinoma 540 99.40 Very High Very High Very High
Pancreatitis 60 98.60 Very High Very High Very High
Cancer 969 98.52 Very High Very High Very High
Metastasis 28 97.48 Very High Very High Very High
Autoimmune Disease 19 95.88 Very High Very High Very High
Rheumatoid Arthritis 28 91.40 High High
Systemic Lupus Erythematosus 30 90.88 High High
Squamous Cell Carcinoma 64 90.84 High High
INFLAMMATION 257 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Gene_expression (expression) of PDL-1 in PDL-1 associated with adenocarcinoma
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.24 Pain Relevance 0.21
Expression of the negative costimulatory molecule PDL-1 by MDCs differed between PDAC and CP with increased expression on cells from PDAC but not from CP (Figure 4A and 6).
Gene_expression (Expression) of PDL-1 in PDL-1 associated with adenocarcinoma and chronic pancreatitis
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.62 Pain Relevance 0.57
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Gene_expression (levels) of PDL-1 in CD86
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
The PDL-1 is expressed on monocytes and mature DCs and exerts inhibitory effects on CD4+ T cell activation [46], [47].
Gene_expression (expressed) of PDL-1 in T cell
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.83 Pain Relevance 0.17
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Gene_expression (expression) of PDL-1 in PDL-1 associated with adenocarcinoma
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.30 Pain Relevance 0.24
The levels of PDL-1 and B7H3 were increased on MDCs pre surgery (median 245, median 5.1) and post surgery (median 252, median 5.2) compared to controls (median 164, median 3.3).
Gene_expression (levels) of PDL-1 in PDL-1
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.54 Pain Relevance 0
Lack of B7H1 and B7H4 expression is a strong predictor of overall survival in patients without metastases [25-28].
Gene_expression (expression) of B7H1 associated with metastasis
7) Confidence 0.38 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667482 Disease Relevance 0.96 Pain Relevance 0
Monocytes alone or untreated NK cells in the presence or absence of monocytes were not able to elevate B7H1 expression on the surface of hMSCs (data not shown).
Gene_expression (expression) of B7H1 in Monocytes
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0
Moreover, when hMSCs were cultured with IL-2 treated NK cells alone or IL-2 treated NK cells with monocytes significant induction of B7H1 surface expression could be observed in surviving hMSCs (Fig. 5H).
Gene_expression (expression) of B7H1 in NK cells
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.07 Pain Relevance 0
The intensity of NK cell induced B7H1 expression on hMSCs were similar to that induced by the treatment of hMSCs with IFN-?
Gene_expression (expression) of B7H1 in NK cell
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0.03
The ligands for PD-1 have been identified as PD-L1 (B7-H1), which is expressed in all haemopoietic cells as well as in many non-haemopoietic tissues, and PD-L2 (B7-DC), which is expressed primarily on dendritic cells and macrophages [14,16,18,19].
Gene_expression (expressed) of PD-L1 in macrophages
11) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.73 Pain Relevance 0.34
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Gene_expression (expression) of B7H1
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.44 Pain Relevance 0
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Gene_expression (expression) of B7H1
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.43 Pain Relevance 0.03
were observed when NK cells were co-incubated with UCLA-OSCSCs which released significantly lower levels of GM-CSF, IL-6 and IL-8 (Tables 1 and 2) and demonstrated decreased expression of phospho-Stat3, B7H1 and EGFR, and much lower constitutive NF?
Gene_expression (expression) of B7H1 in NK cells
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.47 Pain Relevance 0.12
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Neg (no) Gene_expression (expression) of B7H1
15) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.43 Pain Relevance 0
by the NK cells and elevation of B7H1 surface expression on the stem cells (Figs. 4 and 5).
Gene_expression (expression) of B7H1 in stem cells
16) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0.07
2, IDO, and PDL-1 on GBM immunosuppressive properties on T-cell functions in a tumour-specific T-cell model [132].
Gene_expression (immunosuppressive) of PDL-1 in T-cell associated with cancer and glioblastoma
17) Confidence 0.06 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 1.14 Pain Relevance 0.07
The ligands for PD-1 have been identified as PD-L1 (B7-H1), which is expressed in all haemopoietic cells as well as in many non-haemopoietic tissues, and PD-L2 (B7-DC), which is expressed primarily on dendritic cells and macrophages [14,16,18,19].
Gene_expression (expressed) of PD-L1 in dendritic cells
18) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.73 Pain Relevance 0.34
PDL, PDL/fibronectin, and PDL/laminin were left on dishes overnight in a humidified 37°C, 5% CO2 incubator, and then the excess substrate was removed and dishes were rinsed with PBS.
Gene_expression (left) of PDL
19) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.22 Pain Relevance 0
PDL, PDL/fibronectin, and PDL/laminin were left on dishes overnight in a humidified 37°C, 5% CO2 incubator, and then the excess substrate was removed and dishes were rinsed with PBS.
Gene_expression (left) of PDL
20) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.22 Pain Relevance 0

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