INT203049

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.15
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDCD1) plasma membrane (PDCD1) signal transducer activity (PDCD1)
Anatomy Link Frequency
T cells 4
PDCD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 180 99.38 Very High Very High Very High
rheumatoid arthritis 45 98.16 Very High Very High Very High
tolerance 12 82.08 Quite High
Serotonin 7 58.64 Quite High
cytokine 6 58.56 Quite High
sNRI 4 54.88 Quite High
Inflammation 9 53.72 Quite High
depression 2 51.12 Quite High
Lasting pain 2 27.52 Quite Low
antidepressant 1 25.52 Quite Low
Disease Link Frequency Relevance Heat
Death 6 100.00 Very High Very High Very High
Seronegative Spondarthritis 204 99.38 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 99.20 Very High Very High Very High
Apoptosis 16 99.20 Very High Very High Very High
Systemic Lupus Erythematosus 60 98.68 Very High Very High Very High
Viral Infection 1 98.60 Very High Very High Very High
Rheumatoid Arthritis 45 98.16 Very High Very High Very High
Disease 72 96.76 Very High Very High Very High
Renal Disease 8 94.64 High High
Diabetes Mellitus 5 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PD-1 molecule is a negative regulator of T cells [13] that belongs to the immunoglobulin receptor superfamily.
Negative_regulation (regulator) of PD-1 molecule in T cells
1) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 1.34 Pain Relevance 0.64
Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population

The PD-1 (programmed death 1) molecule is a negative regulator of T cells.

Negative_regulation (regulator) of PD-1 in T cells associated with spinal inflammation, apoptosis and death
2) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1794506 Disease Relevance 1.07 Pain Relevance 0.63
Ferreiros-Vidal and colleagues [9] studied PD-1.1, PD-1.2, PD-1.3, PD-1.5, PD-1.6 and PD-1.9 SNPs in Spanish patients with SLE.
Negative_regulation (studied) of PD-1 associated with systemic lupus erythematosus
3) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 1.36 Pain Relevance 0.45
Ferreiros-Vidal and colleagues [9] studied PD-1.1, PD-1.2, PD-1.3, PD-1.5, PD-1.6 and PD-1.9 SNPs in Spanish patients with SLE.
Negative_regulation (studied) of PD-1 associated with systemic lupus erythematosus
4) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 1.42 Pain Relevance 0.46
CTLA4, like PDCD1, is a negative regulator of T-cell activation [32], and polymorphisms in this gene are associated with the onset of GD [33], [34].
Negative_regulation (regulator) of PDCD1 in T-cell associated with disease
5) Confidence 0.42 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.33 Pain Relevance 0.12
Blockade of PD-1 has been associated with enhanced CD8+ T cell response [55], [56].
Negative_regulation (Blockade) of PD-1 in T cell
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.62 Pain Relevance 0.06

General Comments

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