INT20305

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 19.75
Pain Relevance 19.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 6
hepatocyte 5
brain 5
neurons 3
substantia nigra 2
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1132 99.92 Very High Very High Very High
Nicotine 42 99.62 Very High Very High Very High
withdrawal 15 99.50 Very High Very High Very High
Thalamus 6 99.48 Very High Very High Very High
cytokine 14 98.84 Very High Very High Very High
alcohol 109 98.40 Very High Very High Very High
Hippocampus 12 97.72 Very High Very High Very High
member 8 2 96.48 Very High Very High Very High
Substantia nigra 16 95.96 Very High Very High Very High
Pyramidal cell 6 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 59 99.76 Very High Very High Very High
Urological Neuroanatomy 12 99.68 Very High Very High Very High
Nicotine Addiction 18 99.60 Very High Very High Very High
Diabetes Mellitus 38 99.56 Very High Very High Very High
Alcoholic Liver Diseases 51 99.52 Very High Very High Very High
Hepatotoxicity 66 99.36 Very High Very High Very High
Toxicity 141 99.30 Very High Very High Very High
Injury 58 99.20 Very High Very High Very High
Death 343 98.96 Very High Very High Very High
Apoptosis 112 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of cytochrome P450 2E1 (CYP2E1) occurs in alcoholic liver disease, and leads to the hepatocellular generation of toxic reactive oxygen intermediates (ROI).
Gene_expression (expression) of CYP2E1 in liver associated with alcoholic liver diseases
1) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.49 Pain Relevance 0.04
Increased expression of CYP2E1 conferred hepatocyte resistance to ROI-induced cytotoxicity, which was mediated in part by GSH.
Gene_expression (expression) of CYP2E1 in hepatocyte
2) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.90 Pain Relevance 0.11
Increased expression of cytochrome P450 2E1 (CYP2E1) occurs in alcoholic liver disease, and leads to the hepatocellular generation of toxic reactive oxygen intermediates (ROI).
Gene_expression (expression) of cytochrome P450 2E1 in liver associated with alcoholic liver diseases
3) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.49 Pain Relevance 0.04
To determine the effect of CYP2E1 expression on the hepatocellular response to injury, stably transfected hepatocytes expressing increased (S-CYP15) and decreased (AN-CYP10) levels of CYP2E1 were generated from the rat hepatocyte line RALA255-10G.
Gene_expression (expression) of CYP2E1 in hepatocyte associated with injury
4) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.72 Pain Relevance 0.12
To determine the effect of CYP2E1 expression on the hepatocellular response to injury, stably transfected hepatocytes expressing increased (S-CYP15) and decreased (AN-CYP10) levels of CYP2E1 were generated from the rat hepatocyte line RALA255-10G.
Gene_expression (levels) of CYP2E1 in hepatocyte associated with injury
5) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.85 Pain Relevance 0.13
Oxidative stress created by CYP2E1 overexpression may promote liver cell injury by sensitizing hepatocytes to oxidant-induced damage from Kupffer cell-produced ROI or cytokines.
Gene_expression (overexpression) of CYP2E1 in hepatocytes associated with stress, injury and cytokine
6) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.64 Pain Relevance 0.10
However, CYP2E1 overexpression left cells vulnerable to death from GSH depletion.
Gene_expression (overexpression) of CYP2E1 associated with death
7) Confidence 0.78 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.91 Pain Relevance 0.10
Cytochrome P450 2E1 (CYP2E1) has been detected in brain regions which are of relevance for the pathophysiology of Parkinson's disease, such as the substantia nigra (SN).
Gene_expression (detected) of CYP2E1 in substantia nigra associated with substantia nigra and disease
8) Confidence 0.78 Published 2008 Journal Synapse Section Abstract Doc Link 18288650 Disease Relevance 0.18 Pain Relevance 0.29
Smokers have higher levels of brain CYP2E1 expression than non-smokers, but the specific regions and cell types which have the higher expression differ from nicotine-induced rat brain.
Gene_expression (expression) of CYP2E1 in brain associated with nicotine addiction and nicotine
9) Confidence 0.78 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.26 Pain Relevance 0.32
We therefore investigated the expression and distribution of brain CYP2E1 in a non-human primate, the African green monkey, and determined the effect of nicotine treatment.
Spec (investigated) Gene_expression (expression) of CYP2E1 in brain associated with nicotine
10) Confidence 0.78 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.26 Pain Relevance 0.43
Chronic nicotine treatment induced CYP2E1 expression in the frontal cortex (1.5-fold, P < 0.05) and cerebellum (1.5-fold, P < 0.01), specifically in cortical pyramidal neurons and cerebellar Purkinje cells but no change was seen in temporal cortex (P = 0.20), hippocampus (P = 0.29), putamen (P = 0.26) and thalamus (P = 0.08).
Gene_expression (expression) of CYP2E1 in Purkinje cells associated with pyramidal cell, nicotine, urological neuroanatomy, thalamus and hippocampus
11) Confidence 0.78 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.39 Pain Relevance 0.50
CYP2E1 is expressed in liver and extrahepatic tissues, including brain.
Gene_expression (expressed) of CYP2E1 in brain
12) Confidence 0.78 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.15 Pain Relevance 0.23
CYP2E1 expression pattern in monkey brain following chronic nicotine treatment is similar to that in smokers, suggesting that nicotine may be the primary component in cigarette smoke that induces CYP2E1.
Gene_expression (expression) of CYP2E1 in brain associated with nicotine addiction and nicotine
13) Confidence 0.78 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.41 Pain Relevance 0.50
Five millimoles acetaminophen decreased proliferation of CYP2E1-overexpressing HepG2 cells, increased cytosolic Ca2+ levels and produced significant cytotoxicity, while only little, mostly anti-proliferative effects were found in HepG2 cells lacking CYP2E1.
Gene_expression (overexpressing) of CYP2E1 associated with paracetamol
14) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242817 Disease Relevance 0.08 Pain Relevance 0.51
Acetaminophen alters microsomal ryanodine Ca2+ channel in HepG2 cells overexpressing CYP2E1.
Gene_expression (overexpressing) of CYP2E1 associated with paracetamol
15) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15242817 Disease Relevance 0.10 Pain Relevance 0.53
In the cells engineered to overexpress CYP2E1, an increased [3H]ryanodine affinity (by 45%) and increased ligand maximal binding to ryanodine receptors (by 64%) was observed, most probably due to increased association rate of [3H]ryanodine.
Gene_expression (overexpress) of CYP2E1
16) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242817 Disease Relevance 0.06 Pain Relevance 0.58
Acetaminophen cytotoxicity was significantly higher in CYP2E1 expressing cells with depleted glutathione.
Gene_expression (expressing) of CYP2E1 associated with paracetamol
17) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242817 Disease Relevance 0.07 Pain Relevance 0.54
However, the expression of CYP2E1 in the livers of hypothyroid rats, as measured by western blot analysis, was not decreased compared to control rats.
Gene_expression (expression) of CYP2E1 in livers
18) Confidence 0.77 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389702 Disease Relevance 1.13 Pain Relevance 0.50
Western blot analysis showed that APAP treatment induced the expression of CYP2E1 and CYP3A proteins.
Gene_expression (expression) of CYP2E1 associated with paracetamol
19) Confidence 0.76 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17620348 Disease Relevance 0.06 Pain Relevance 0.85
In microsomes engineered to express individual human P450s, SAM produced a type II binding spectrum with CYP2E1-, but not with CYP3A4-expressing microsomes, and SAM was a weaker inhibitor against the metabolism of a specific CYP3A4 substrate than a specific CYP2E1 substrate.
Neg (not) Gene_expression (produced) of CYP2E1
20) Confidence 0.76 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763544 Disease Relevance 0 Pain Relevance 0.14

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