INT203050

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 12.93
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDCD1) plasma membrane (PDCD1) signal transducer activity (PDCD1)
Anatomy Link Frequency
T-cell 1
PDCD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 325 99.92 Very High Very High Very High
rheumatoid arthritis 92 99.60 Very High Very High Very High
Serotonin 21 89.76 High High
sNRI 12 86.00 High High
depression 6 82.24 Quite High
tolerance 29 73.84 Quite High
Lasting pain 6 58.64 Quite High
Inflammation 17 57.32 Quite High
antidepressant 3 56.64 Quite High
abatacept 3 33.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 49 100.00 Very High Very High Very High
Seronegative Spondarthritis 357 99.92 Very High Very High Very High
Disease 210 99.80 Very High Very High Very High
Rheumatoid Arthritis 97 99.60 Very High Very High Very High
Renal Disease 24 99.12 Very High Very High Very High
Syndrome 117 98.72 Very High Very High Very High
Autoimmune Disease 49 97.96 Very High Very High Very High
Systemic Lupus Erythematosus 115 94.88 High High
Diabetes Mellitus 24 88.60 High High
Death 20 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Case-control genetic association studies were performed to test the association between PDCD1 and the development of AS.
PDCD1 Binding (association) of associated with spinal inflammation
1) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.81 Pain Relevance 0.52
Genetic studies, published after May 1, 2007 (which was not used for constructing the relationship between PDCD1 and GD) showed that small genetic effects within PDCD1 contribute to the development of GD [30], [31], and confirms that the proposed association between PDCD1 and GD by CoPub Discovery is indeed biologically relevant.
PDCD1 Binding (association) of associated with disease
2) Confidence 0.47 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.44 Pain Relevance 0.04
It is therefore possible that AS is associated with the function of the PD-1 molecule.
PD-1 molecule Binding (associated) of associated with spinal inflammation
3) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 1.41 Pain Relevance 0.47
This functional association between PDCD1 and CTLA4 explains the relationship between PDCD1 and GD, and indicates that the CoPub Discovery predicted association between PDCD1 and GD was correctly identified based on biological knowledge.


PDCD1 Binding (association) of associated with disease
4) Confidence 0.36 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.20 Pain Relevance 0.27
This functional association between PDCD1 and CTLA4 explains the relationship between PDCD1 and GD, and indicates that the CoPub Discovery predicted association between PDCD1 and GD was correctly identified based on biological knowledge.


PDCD1 Binding (association) of associated with disease
5) Confidence 0.36 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.28 Pain Relevance 0.44
Unexpectedly, no association with PDCD1 was observed in HLA-DR4 and HLA-DRw53 positive or negative VKH patients.
PDCD1 Neg (no) Binding (association) of
6) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 0.51 Pain Relevance 0
It is not clear whether this association is present in other ethnic VKH patients and whether other PDCD1 polymorphisms are associated with the susceptibility to VKH syndrome.
PDCD1 Binding (associated) of associated with syndrome
7) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 0.41 Pain Relevance 0.11
To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population.


PDCD1 Spec (analyze) Binding (association) of associated with syndrome and apoptosis
8) Confidence 0.36 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2645903 Disease Relevance 0.37 Pain Relevance 0
The present study investigated the association of the PD-1 polymorphisms and the haplotypes with AS in a Korean population sample.
PD-1 Binding (association) of associated with spinal inflammation
9) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794506 Disease Relevance 1.03 Pain Relevance 0.63
This study therefore investigated whether or not PDCD1 is associated with AS in the Korean population.


PDCD1 Binding (associated) of associated with spinal inflammation
10) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.81 Pain Relevance 0.49
It was also suggested that lupus nephritis and the seronegative RA susceptibility was associated with the PD-1.3 (position 7,146) A allele in a northern Sweden population.
PD-1 Binding (associated) of associated with renal disease and rheumatoid arthritis
11) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 1.41 Pain Relevance 0.67
Genotyping of PD-1.5 and 1.9
PD-1 Binding (Genotyping) of
12) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.35 Pain Relevance 0.17
To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population.


death 1 Spec (analyze) Binding (association) of associated with syndrome and apoptosis
13) Confidence 0.31 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2645903 Disease Relevance 0.36 Pain Relevance 0
However, PD-1.5 may be negatively associated with the occurrence of extraocular manifestations of VKH syndrome.



PD-1 Binding (associated) of associated with syndrome
14) Confidence 0.31 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2645903 Disease Relevance 0.52 Pain Relevance 0
The results suggest a genetic association between the PD-1 polymorphism and susceptibility to AS.



PD-1 Binding (association) of associated with spinal inflammation
15) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794506 Disease Relevance 0.96 Pain Relevance 0.67
PD-1 ligation transmits a potent inhibitory signal in the early stages of T-cell activation.
PD-1 Binding (ligation) of in T-cell
16) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.08 Pain Relevance 0

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