INT203067

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.92
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trim63) intracellular (Trim63) ligase activity (Trim63)
cytoplasm (Trim63)
Anatomy Link Frequency
myocardium 2
spinal cord 2
finger 2
Trim63 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 98.18 Very High Very High Very High
Inflammation 20 80.24 Quite High
cytokine 22 70.60 Quite High
Osteoarthritis 23 56.20 Quite High
chemokine 3 53.32 Quite High
Arthritis 4 32.36 Quite Low
nalbuphine 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 8 97.76 Very High Very High Very High
Muscular Atrophy 4 85.40 High High
INFLAMMATION 22 80.24 Quite High
Coronary Heart Disease 4 79.00 Quite High
Sepsis 12 67.36 Quite High
Osteoarthritis 23 56.20 Quite High
Heart Rate Under Development 20 55.40 Quite High
Arthritis 11 32.36 Quite Low
Necrosis 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar observations have also been made in the gastrocnemius and soleus muscles of rats subjected to spinal cord isolation, where brief bouts of high-load isometric contractions were able to prevent the increased expression of MAFbx/atrogin-1 and MuRF1 mRNA [35].
Positive_regulation (increased) of Gene_expression (expression) of MuRF1 mRNA in spinal cord associated with spinal cord
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.26 Pain Relevance 0.05
In further support of this notion, elevated levels of MAFbx/atrogin-1 and MuRF1 mRNA have been observed in the myocardium following chronic heart failure induced via the ligation of the left coronary artery, a condition where reduced contractile activity of the myocardium is observed [36] and, more importantly, regular exercise training has been shown to be sufficient to significantly reduce myocardial MAFbx/atrogin-1 and MuRF1 mRNA levels following experimental myocardial infarction in rats [37].
Positive_regulation (elevated) of Gene_expression (levels) of MuRF1 mRNA in myocardium associated with myocardial infarction
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.31 Pain Relevance 0.07
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of Gene_expression (/) of MuRF1 mRNA
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of Gene_expression (/) of MuRF1
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
Expression of two of the exceptions, MMP-13 and ring finger protein 28, was found similarly enhanced by glucosamine alone.
Positive_regulation (enhanced) of Gene_expression (Expression) of ring finger protein 28 in finger
5) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.14 Pain Relevance 0.12

General Comments

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