INT20307

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 8
Speculated 2
Reported most in Abstract
Documents 70
Total Number 76
Disease Relevance 23.59
Pain Relevance 32.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 5
brain 5
hepatocytes 3
hippocampus 2
neurons 2
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 8 100.00 Very High Very High Very High
Paracetamol 1110 99.98 Very High Very High Very High
Hippocampus 28 99.90 Very High Very High Very High
Nicotine 121 99.84 Very High Very High Very High
alcohol 201 99.74 Very High Very High Very High
tolerance 4 99.44 Very High Very High Very High
withdrawal 21 98.84 Very High Very High Very High
adenocard 4 97.26 Very High Very High Very High
Bioavailability 1 95.72 Very High Very High Very High
cytokine 13 94.76 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 123 99.92 Very High Very High Very High
Stress 45 99.88 Very High Very High Very High
Urological Neuroanatomy 28 99.84 Very High Very High Very High
Toxicity 183 99.82 Very High Very High Very High
Injury 64 99.54 Very High Very High Very High
Nicotine Addiction 54 99.54 Very High Very High Very High
Overdose 49 98.78 Very High Very High Very High
Alcoholic Liver Diseases 87 97.72 Very High Very High Very High
Death 248 96.28 Very High Very High Very High
Necrosis 26 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nicotine from tobacco smoke may contribute to the enhanced hepatic CYP2E1 activity in smokers.
Positive_regulation (enhanced) of CYP2E1 associated with nicotine addiction and nicotine
1) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.26 Pain Relevance 0.36
We have previously shown that chronic nicotine treatment can increase CYP2E1 in rat liver and brain.
Positive_regulation (increase) of CYP2E1 in brain associated with nicotine
2) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.32 Pain Relevance 0.40
Brain CYP2E1 mRNA levels did not increase after chronic nicotine treatment, suggesting nontranscriptional regulation.
Neg (not) Positive_regulation (increase) of CYP2E1 in Brain associated with nicotine
3) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.63 Pain Relevance 0.52
In contrast, acute nicotine treatment did not induce CYP2E1 in frontal cortex and hippocampus but increased CYP2E1 in cerebellum 8 h after treatment (1.6-fold, p < 0.01).
Neg (not) Positive_regulation (increased) of CYP2E1 in frontal cortex associated with nicotine, urological neuroanatomy and hippocampus
4) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.61 Pain Relevance 0.52
In contrast, acute nicotine treatment did not induce CYP2E1 in frontal cortex and hippocampus but increased CYP2E1 in cerebellum 8 h after treatment (1.6-fold, p < 0.01).
Neg (not) Positive_regulation (induce) of CYP2E1 in frontal cortex associated with nicotine, urological neuroanatomy and hippocampus
5) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.60 Pain Relevance 0.52
In this study, induction of brain CYP2E1 was assessed after a single acute or a 7-day chronic treatment with saline or nicotine (1 mg/kg s.c.), with sacrifice performed at various times after the last injection.
Positive_regulation (induction) of CYP2E1 in brain associated with nicotine
6) Confidence 0.70 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16434548 Disease Relevance 0.33 Pain Relevance 0.41
Maximal CYP2E1 induction was caused by 36% energy as ethanol diet (2.2-fold, p < 0.05 versus control).
Positive_regulation (induction) of CYP2E1
7) Confidence 0.70 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 12433812 Disease Relevance 0.44 Pain Relevance 0.66
S-CYP15 cells had increased levels of CYP2E1 as demonstrated by Northern blot analysis, immunoblotting, catalytic activity, and increased cell sensitivity to death from acetaminophen.
Positive_regulation (increased) of CYP2E1 associated with paracetamol and death
8) Confidence 0.70 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.93 Pain Relevance 0.14
Chronic alcohol consumption may potentiate acetaminophen (APAP) hepatotoxicity through enhanced formation of N-acetyl-p-benzoquinone imine (NAPQI) via induction of cytochrome P450 2E1 (CYP2E1).
Positive_regulation (induction) of CYP2E1 associated with paracetamol, hepatotoxicity and alcohol
9) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.37 Pain Relevance 0.45
However, CYP2E1 induction appears to be insufficient to explain the claimed magnitude of the interaction.
Positive_regulation (induction) of CYP2E1
10) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.37 Pain Relevance 0.44
Ethanol induced CYP2E1 in both the 10-day and 6-week groups by approximately 2-fold.
Positive_regulation (induced) of CYP2E1
11) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.51 Pain Relevance 0.58
Chronic alcohol consumption may potentiate acetaminophen (APAP) hepatotoxicity through enhanced formation of N-acetyl-p-benzoquinone imine (NAPQI) via induction of cytochrome P450 2E1 (CYP2E1).
Positive_regulation (induction) of cytochrome P450 2E1 associated with paracetamol, hepatotoxicity and alcohol
12) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.37 Pain Relevance 0.45
In conclusion, 10-day ethanol feeding enhances APAP toxicity through CYP2E1 induction, whereas 6-week ethanol feeding potentiates APAP hepatotoxicity by inducing CYP2E1 and selectively depleting mitochondrial GSH.
Positive_regulation (induction) of CYP2E1 associated with toxicity, paracetamol and hepatotoxicity
13) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.53 Pain Relevance 0.55
In conclusion, 10-day ethanol feeding enhances APAP toxicity through CYP2E1 induction, whereas 6-week ethanol feeding potentiates APAP hepatotoxicity by inducing CYP2E1 and selectively depleting mitochondrial GSH.
Positive_regulation (inducing) of CYP2E1 associated with toxicity, paracetamol and hepatotoxicity
14) Confidence 0.70 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.51 Pain Relevance 0.49
Increased CYP2E1 in brain may contribute to oxidative stress and alter localized metabolism, and resulting pharmacology, of centrally acting drugs metabolized by CYP2E1.
Positive_regulation (Increased) of CYP2E1 in brain associated with stress
15) Confidence 0.70 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.40 Pain Relevance 0.46
CYP2E1 expression pattern in monkey brain following chronic nicotine treatment is similar to that in smokers, suggesting that nicotine may be the primary component in cigarette smoke that induces CYP2E1.
Positive_regulation (induces) of CYP2E1 in brain associated with nicotine addiction and nicotine
16) Confidence 0.70 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.40 Pain Relevance 0.46
In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment.
Positive_regulation (induction) of CYP2E1 associated with nicotine
17) Confidence 0.69 Published 2006 Journal Drug Metab. Dispos. Section Title Doc Link 16763012 Disease Relevance 0.18 Pain Relevance 0.08
Nicotine is one component in cigarette smoke that can increase in vivo CZN metabolism via induction of hepatic CYP2E1 levels.
Positive_regulation (induction) of CYP2E1 associated with nicotine
18) Confidence 0.69 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16763012 Disease Relevance 0 Pain Relevance 0.31
This mean increase was similar in magnitude to that predicted by a mathematical model describing the induction of CYP2E1, the main enzyme catalyzing NAPQI formation, by a mechanism of enzyme stabilization.
Positive_regulation (induction) of CYP2E1
19) Confidence 0.69 Published 2000 Journal Clin. Pharmacol. Ther. Section Body Doc Link 10872641 Disease Relevance 0.07 Pain Relevance 0
The ethanol increased the hepatic microsomal CYP2E1 level and the rate of dimethylnitrosamine (DMN) demethylation.
Positive_regulation (increased) of CYP2E1
20) Confidence 0.69 Published 1999 Journal Hepatology Section Abstract Doc Link 9862862 Disease Relevance 0.37 Pain Relevance 0.41

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