INT203116

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.98
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACAN) cell adhesion (ACAN) proteinaceous extracellular matrix (ACAN)
Anatomy Link Frequency
T-cell 2
chondrocytes 1
ACAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 117 99.60 Very High Very High Very High
Arthritis 209 98.36 Very High Very High Very High
metalloproteinase 75 95.60 Very High Very High Very High
cytokine 51 32.64 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
rheumatoid arthritis 21 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 133 99.60 Very High Very High Very High
Disease 51 99.36 Very High Very High Very High
Juvenile Chronic Polyarthritis 180 98.36 Very High Very High Very High
Obesity 104 97.88 Very High Very High Very High
Overweight 13 82.08 Quite High
Apoptosis 4 14.16 Low Low
INFLAMMATION 23 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 22 5.00 Very Low Very Low Very Low
Experimental Arthritis 20 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An elevated level of aggrecan mRNA was also found at 500 ng/ml of leptin for both BMI patient groups, but the difference with unstimulated cells did not reach statistical significance.
Positive_regulation (elevated) of aggrecan associated with obesity
1) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.75 Pain Relevance 0.07
Physiological tonicity also significantly increased AGC1 (Figure 3a) and SOX9 (Figure 3b) mRNA levels in nonosteoarthritic human articular chondrocytes (NHACs).
Positive_regulation (increased) of AGC1 in chondrocytes
2) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0.07
Physiological tonicity (380 mOsm) during isolation and subsequent passaging of OA HACs significantly increased mRNA levels of both AGC1 (Figure 2a) and SOX9 (Figure 2b) at all passages.
Positive_regulation (increased) of AGC1 associated with osteoarthritis
3) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.25 Pain Relevance 0.13
T-cell responses to aggrecan and fibrillin are related to disease subtype
Positive_regulation (responses) of aggrecan in T-cell associated with disease
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.39 Pain Relevance 0.64
T-cell responses to aggrecan are related to disease duration
Positive_regulation (responses) of aggrecan in T-cell associated with disease
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.39 Pain Relevance 0.67
After 3 weeks, aggrecan gene expression level was elevated to 1.3 (p = 0.45 [1 week], p = 0.35 [2 weeks], p = 0.34 [3 weeks]).
Positive_regulation (elevated) of aggrecan gene
6) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.06 Pain Relevance 0

General Comments

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