INT203137

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 9.46
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
macrophage 2
blood vessels 1
endothelial cell 1
leukocyte 1
colon 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 25 100.00 Very High Very High Very High
Inflammation 192 99.30 Very High Very High Very High
cytokine 90 98.52 Very High Very High Very High
COX2 2 97.08 Very High Very High Very High
chemokine 25 96.16 Very High Very High Very High
Arthritis 102 94.44 High High
rheumatoid arthritis 101 82.80 Quite High
antagonist 7 81.56 Quite High
Inflammatory response 47 73.76 Quite High
Central nervous system 22 59.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 269 100.00 Very High Very High Very High
Cancer 96 100.00 Very High Very High Very High
Death 18 99.64 Very High Very High Very High
Hyperplasia 3 99.60 Very High Very High Very High
Apoptosis 53 99.56 Very High Very High Very High
Breast Cancer 8 98.62 Very High Very High Very High
Colon Cancer 8 97.92 Very High Very High Very High
Sepsis 100 96.88 Very High Very High Very High
Arthritis 109 94.44 High High
Togavirus Infection 150 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cytokine expression at the site of inflammation is suggested to be the outcome of interaction of glucocorticoids and macrophage migration inhibitory factor (Mif) [24-26].
Mif Binding (interaction) of in macrophage associated with inflammation and cytokine
1) Confidence 0.31 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.84 Pain Relevance 0.49
Through the activation of MAP kinases MIF enhances the differentiation of endothelial cells to blood vessels.45,46 In human breast cancer cells, MIF over-expression correlates with IL-8 and VEGF expression associated with angiogenesis.47

MIF, enzymatic activity and tumour progression

MIF Binding (associated) of in blood vessels associated with cancer and breast cancer
2) Confidence 0.31 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.09 Pain Relevance 0.05
In addition, MIF added exogenously to a human colon adenocarcinoma cell line promoted anchorage-independent growth of the cells and inhibited cell death.27As well as its interactions with tumour suppressors, MIF promotes cellular proliferation through activation of members of the MAPK family.
MIF Binding (interactions) of in colon associated with cancer, colon cancer, hyperplasia and death
3) Confidence 0.30 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.21 Pain Relevance 0.09
The cytokine expression at the site of inflammation is suggested to be the outcome of interaction of glucocorticoids and macrophage migration inhibitory factor (Mif) [24-26].
migration inhibitory factor Binding (interaction) of in macrophage associated with inflammation and cytokine
4) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.84 Pain Relevance 0.49
Thus, many known (such as HMGB1, C5a and MIF)
         or as yet unidentified pro-inflammatory mediators may synergistically interact with each
         other and collectively contribute to the pathogenesis of sepsis.


MIF Binding (interact) of associated with inflammatory mediators and sepsis
5) Confidence 0.15 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.02 Pain Relevance 0.14
Finally, MIF recruits monocytes/macrophages to the site of inflammation through CCL2 induction [117], or acting as a chemokine ligand on endothelial cell surfaces by directly binding to CXCR2 [118].


MIF Binding (recruits) of in endothelial cell associated with chemokine and inflammation
6) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.01 Pain Relevance 0.57
However, human but not mouse oncostatin M binds the leukocyte migration inhibitory factor receptor and human oncostatin M did not bind to the mouse oncostatin M receptor [64].
migration inhibitory factor Binding (binds) of in leukocyte
7) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.46 Pain Relevance 0.88

General Comments

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