INT203154

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.68
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synovial fluid 2
osteoblasts 2
neutrophils 2
Lts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 457 99.60 Very High Very High Very High
Inflammation 40 97.60 Very High Very High Very High
Pain 75 95.40 Very High Very High Very High
COX-2 inhibitor 17 93.36 High High
cINOD 48 91.60 High High
Inflammatory response 4 88.32 High High
cytokine 1 74.48 Quite High
analgesia 10 73.12 Quite High
Serotonin 17 50.00 Quite Low
unmyelinated 3 45.08 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 462 99.60 Very High Very High Very High
INFLAMMATION 59 97.60 Very High Very High Very High
Pain 87 95.40 Very High Very High Very High
Targeted Disruption 9 70.56 Quite High
Neurogenic Inflammation 1 61.40 Quite High
Disease 17 59.60 Quite High
Hypercalcemia 20 50.48 Quite High
Hypoxia 1 16.84 Low Low
Recurrence 1 16.68 Low Low
Necrosis 1 12.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparison of results obtained by LTS and HTS
Positive_regulation (by) of Gene_expression (obtained) of LTS
1) Confidence 0.17 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.07 Pain Relevance 0
The production of LTs requires active 5-LO in the presence of calcium [25,26], yet arachidonic acid must be presented by the 5-LO-activating protein [25,27].
Positive_regulation (requires) of Gene_expression (production) of LTs
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.49 Pain Relevance 0.27
However, the inhibition of the production of LTs in macrophages is due to high PGE2 levels as a result of an increase in IL-10 [24], whereas in neutrophils IL-18 stimulates the production of LTs [32].
Positive_regulation (stimulates) of Gene_expression (production) of LTs in neutrophils
3) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.38 Pain Relevance 0.22
These results indicate that the balance of PGE2 levels in OA osteoblasts is actually driving the expression of LTs, and conversely that chronic inhibition of COX may be leading to the synthesis of LTs.
Positive_regulation (leading) of Gene_expression (synthesis) of LTs in osteoblasts associated with osteoarthritis
4) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.71 Pain Relevance 0.45
The long-term treatment of OA patients with selective inhibitors of COX-2 could promote the production of LTs.
Positive_regulation (promote) of Gene_expression (production) of LTs associated with osteoarthritis
5) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.86 Pain Relevance 0.68
The development and severity of OA correlates with an increasing expression of cartilage-degrading enzymes, prostaglandins (PGs) and leukotrienes (LTs) in synovial fluid.
Positive_regulation (increasing) of Gene_expression (expression) of LTs in synovial fluid associated with osteoarthritis
6) Confidence 0.01 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 1.17 Pain Relevance 1.05

General Comments

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