INT203162

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
plasma membrane (PTGER2) enzyme binding (ALOX5AP) signal transducer activity (PTGER2)
Anatomy Link Frequency
osteoblasts 2
PTGER2 (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 210 98.80 Very High Very High Very High
COX-2 inhibitor 6 89.76 High High
Inflammation 10 81.44 Quite High
cINOD 16 73.24 Quite High
Inflammatory response 2 53.76 Quite High
Pain 4 33.76 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 212 98.80 Very High Very High Very High
INFLAMMATION 16 81.44 Quite High
Pain 4 33.76 Quite Low
Hypercalcemia 10 5.00 Very Low Very Low Very Low
Osteoporosis 10 5.00 Very Low Very Low Very Low
Osteophyte 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Sclerosis 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was especially true in the low OA subgroup presenting low PGE2 levels, whereas in the high OA subgroup with already high PGE2 levels the addition of exogenous PGE2 failed to modify FLAP expression.
PGE2 Regulation (modify) of Gene_expression (expression) of FLAP associated with osteoarthritis
1) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.81 Pain Relevance 0.56
In high OA osteoblasts with already high PGE2 levels, the addition of PGE2 failed to modify FLAP expression, whereas inhibiting PGE2 production with NS-398 enhanced FLAP expression about 4-fold (p < 0.025).
PGE2 Regulation (modify) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
2) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.66 Pain Relevance 0.38

General Comments

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