INT203163

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.98
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5) small molecule metabolic process (ALOX5) cytoplasm (ALOX5)
signal transducer activity (LTB4R) cytosol (ALOX5) oxidoreductase activity (ALOX5)
Anatomy Link Frequency
osteoblasts 2
LTB4R (Homo sapiens)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 105 99.80 Very High Very High Very High
cINOD 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 106 99.80 Very High Very High Very High
Osteoporosis 5 81.16 Quite High
Osteophyte 2 31.92 Quite Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Sclerosis 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Metabolic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the shunt from the production of PGE2 to LTB4 is through regulation of the expression of FLAP, not 5-LO, in OA osteoblasts.
LTB4 Regulation (regulation) of Gene_expression (expression) of 5-LO in osteoblasts associated with osteoarthritis
1) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794527 Disease Relevance 0.98 Pain Relevance 0.41

General Comments

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