INT203165

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) plasma membrane (PTGER2)
intracellular (IL10) signal transducer activity (PTGER2) cell-cell signaling (IL10)
Anatomy Link Frequency
osteoblasts 1
IL10 (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 105 97.20 Very High Very High Very High
Inflammation 5 74.44 Quite High
cINOD 8 36.44 Quite Low
COX-2 inhibitor 3 30.92 Quite Low
Inflammatory response 1 16.96 Low Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 106 97.20 Very High Very High Very High
INFLAMMATION 8 74.44 Quite High
Osteoporosis 5 11.60 Low Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Sclerosis 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Metabolic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In subchondral osteoblasts, a link between IL-10 and PGE2 could not be established because IL-10 synthesis by either normal or OA osteoblasts was very low, close to the limit of detection.
IL-10 Binding (link) of PGE2 in osteoblasts associated with osteoarthritis
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.50 Pain Relevance 0.25

General Comments

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