INT203167

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
plasma membrane (PTGER2) enzyme binding (ALOX5AP) signal transducer activity (PTGER2)
Anatomy Link Frequency
osteoblasts 3
PTGER2 (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 105 97.64 Very High Very High Very High
COX-2 inhibitor 3 87.44 High High
cINOD 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 106 97.64 Very High Very High Very High
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Sclerosis 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Metabolic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In high OA osteoblasts with already high PGE2 levels, the addition of PGE2 failed to modify FLAP expression, whereas inhibiting PGE2 production with NS-398 enhanced FLAP expression about 4-fold (p < 0.025).
Gene_expression (production) of PGE2 in osteoblasts Positive_regulation (enhanced) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
1) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.67 Pain Relevance 0.38

General Comments

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