INT203168

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.40
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
plasma membrane (PTGER2) enzyme binding (ALOX5AP) signal transducer activity (PTGER2)
Anatomy Link Frequency
osteoblasts 6
PTGER2 (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 315 100.00 Very High Very High Very High
COX-2 inhibitor 9 89.76 High High
cINOD 24 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 318 100.00 Very High Very High Very High
Osteoporosis 15 69.28 Quite High
Osteophyte 6 69.12 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Hypercalcemia 15 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Sclerosis 6 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Metabolic Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the mechanism responsible for this shunt between the production of PGE2 and that of LTB4 in OA osteoblasts, we then determined the effect of the addition of PGE2 to osteoblasts or of an inhibitor of PGE2 production on the expression of FLAP by real-time PCR.
PGE2 Negative_regulation (inhibitor) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
1) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.62 Pain Relevance 0.35
In high OA osteoblasts with already high PGE2 levels, the addition of PGE2 failed to modify FLAP expression, whereas inhibiting PGE2 production with NS-398 enhanced FLAP expression about 4-fold (p < 0.025).
PGE2 Negative_regulation (failed) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.66 Pain Relevance 0.38
The addition of PGE2 to the low OA osteoblasts subgroup decreased FLAP expression but failed to affect it in the high OA osteoblasts subgroup.
PGE2 Negative_regulation (decreased) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
3) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794527 Disease Relevance 1.12 Pain Relevance 0.45

General Comments

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