INT20317

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Context Info
Confidence 0.81
First Reported 1983
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.68
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) response to stress (Ctsb) lysosome (Ctsb)
Anatomy Link Frequency
skeletal muscle 1
PGE2 1
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 2 98.00 Very High Very High Very High
Analgesic 2 94.64 High High
Inflammation 2 94.08 High High
Enkephalin 5 92.84 High High
bradykinin 8 85.88 High High
lidocaine 2 72.80 Quite High
Chronic pancreatitis 1 61.20 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 98.40 Very High Very High Very High
Pancreatitis 4 94.32 High High
INFLAMMATION 2 94.08 High High
Ulcers 2 87.32 High High
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical localization of cathepsin B in degenerating rat skeletal muscle induced by a local anesthetic, bupivacaine.
Localization (localization) of cathepsin B in skeletal muscle associated with local anesthetic
1) Confidence 0.81 Published 1983 Journal J. Biochem. Section Title Doc Link 6619116 Disease Relevance 0 Pain Relevance 0.19
The purpose of the present study is to examine whether PGE2 could have an effect on activation or release of cathepsin B in the pulp tissue, or not.
Localization (release) of cathepsin B in PGE2
2) Confidence 0.62 Published 1990 Journal Osaka Daigaku Shigaku Zasshi Section Abstract Doc Link 2135403 Disease Relevance 0.17 Pain Relevance 0.87
Hyperamylasaemia, pancreatic oedema and activation of trypsinogen in the pancreatic tissue, as well as subcellular redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction, were prevented by infusion of 20 mg/kg.h cetraxate for 2 h before caerulein infusion and throughout the 3.5 h of caerulein infusion (5 micrograms/kg.h).
Localization (redistribution) of cathepsin B associated with pressure and volume under development
3) Confidence 0.40 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.51 Pain Relevance 0.06

General Comments

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