INT203171

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5) small molecule metabolic process (ALOX5) cytoplasm (ALOX5)
signal transducer activity (PTGER2) cytosol (ALOX5) oxidoreductase activity (ALOX5)
PTGER2 (Homo sapiens)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 105 96.40 Very High Very High Very High
Inflammatory response 1 92.04 High High
COX-2 inhibitor 3 90.64 High High
cINOD 8 89.76 High High
Inflammation 5 87.80 High High
Pain 2 72.04 Quite High
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 106 96.40 Very High Very High Very High
INFLAMMATION 8 91.68 High High
Pain 2 72.04 Quite High
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Sclerosis 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Metabolic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, PGE2 produced via both COX-1 and COX-2 could modulate the activity of 5-LO in these animals, which is reminiscent of the fact that PGE2 inhibits 5-LO activity [55].
PGE2 Negative_regulation (inhibits) of 5-LO
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.89 Pain Relevance 0.77

General Comments

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