INT203173

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 1
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 149 98.60 Very High Very High Very High
COX-2 inhibitor 5 59.76 Quite High
corticosteroid 1 34.24 Quite Low
Inflammation 22 19.84 Low Low
imagery 5 12.08 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
licofelone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 99.84 Very High Very High Very High
Osteoarthritis 154 98.60 Very High Very High Very High
INFLAMMATION 30 19.84 Low Low
Hypercalcemia 5 16.88 Low Low
Death 1 15.44 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 6 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Osteophyte 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined the implication of both 5-LO and FLAP in the production of LTB4 in these cells and the factors that might modulate their expression.
Localization (implication) of FLAP
1) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.36 Pain Relevance 0.21
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Neg (not) Localization (treated) of FLAP in chondrocytes
2) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
Notably, the decreased rate of FRAP and FLAP in disease mutants was much less pronounced than in the Q67L mutant (Fig. 5D–G).
Localization (rate) of FLAP associated with disease
3) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.42 Pain Relevance 0

General Comments

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