INT203178

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.98
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
neutrophils 4
macrophages 3
monocytes 1
IL18 (Homo sapiens)
Lts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 420 99.02 Very High Very High Very High
Inflammation 20 77.40 Quite High
COX-2 inhibitor 12 67.84 Quite High
cINOD 32 39.40 Quite Low
Pain 8 35.20 Quite Low
Inflammatory response 4 19.92 Low Low
corticosteroid 4 18.48 Low Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 424 99.02 Very High Very High Very High
INFLAMMATION 32 77.40 Quite High
Pain 8 35.20 Quite Low
Hypercalcemia 20 24.96 Low Low
Osteoporosis 20 6.48 Low Low
Osteophyte 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Sclerosis 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Metabolic Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A link between IL-18 and PGE2 levels in the synovial fluid of patients with OA of the knee has also been established [47], and IL-18 upregulates LTs production in neutrophils [32].
IL-18 Positive_regulation (upregulates) of Gene_expression (production) of LTs in neutrophils associated with osteoarthritis
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.52 Pain Relevance 0.26
However, the inhibition of the production of LTs in macrophages is due to high PGE2 levels as a result of an increase in IL-10 [24], whereas in neutrophils IL-18 stimulates the production of LTs [32].
IL-18 Positive_regulation (stimulates) of Gene_expression (production) of LTs in neutrophils
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.38 Pain Relevance 0.22
Indeed, PGE2-driven IL-10 synthesis in monocytes/macrophages in vitro has been shown to inhibit LTB4 production by these cells [24], whereas in neutrophils IL-18 stimulates the synthesis of LTs [32].
IL-18 Positive_regulation (stimulates) of Gene_expression (synthesis) of LTs in macrophages
3) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.54 Pain Relevance 0.27
Indeed, PGE2-driven IL-10 synthesis in monocytes/macrophages in vitro has been shown to inhibit LTB4 production by these cells [24], whereas in neutrophils IL-18 stimulates the synthesis of LTs [32].
IL-18 Positive_regulation (stimulates) of in monocytes Gene_expression (synthesis) of LTs in macrophages
4) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.54 Pain Relevance 0.27

General Comments

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