INT20322

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Context Info
Confidence 0.00
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

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small molecule metabolic process (CYP1A2, CYP26A1) endoplasmic reticulum (CYP1A2, CYP26A1) oxidoreductase activity (CYP1A2)
enzyme binding (CYP1A2)
CYP1A2 (Homo sapiens)
CYP26A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 27.92 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Omeprazole produced a time- and concentration-dependent increase in (a) cytochrome P450IA2 accumulation determined by western blot in microsomes from omeprazole-treated cells, while the level of other cytochrome P450 forms including P450IID6, IIE1, and IIIA was not increased in the same culture; (b) several monoxygenase activities, including phenacetin deethylase and acetanilide hydroxylase (cytochrome P450IA2) and ethoxyresorufin deethylase and benzpyrene hydroxylase (cytochrome P450IA1); (c) cytochrome P450IA2 de novo synthesis, determined by immunoprecipitation of cell lysate from [3H]Leu-labeled cells; (d) cytochromes P450IA1 and IA2 mRNAs, determined by northern blot analysis.
cytochrome P450IA2 Binding (activities) of P450IA1
1) Confidence 0.00 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2136526 Disease Relevance 0 Pain Relevance 0

General Comments

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